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solubilizing salicylic acid in propanediol
Has anybody done this? Zemea has this solubility chart but I don’t understand it
S. Acid is soluble in 15% propanediol? how much s. acid? -
9 Replies
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It’s the other way around - 15% or less of sal acid is completely soluble in propanediol, 20% is > a saturated solution.
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L
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Can anybody recommend me where to read about solubility of s.acid?
From what I’m seeing in sample formulas, I’d like to know why surfactants like C14-C16 olefin sulfonate and ethoxylates are used to aid in solubilizing s.acid. -
Joseg - I think you’ll find your answer here - http://www.thedishforum.com/forum/index.php?/topic/164626-solvent-for-salicylic-acid/
(You’ll need to join the forum first to read it though but it’s a useful forum for formulation tips). -
@ChemWizard, The easiest way is to try it for yourself, or look at the ingredient labels of the various products that are already on the market.
Thinking back to the few classes I’ve had on pharmacology, I will also point out that solubilizing active ingredients isn’t always the best method for incorporating them into a preparation. Sometimes, you get more effective activity by using partially soluble or even insoluble active ingredients. -
I’ll just point out here, Jose, that 15% salicylic acid is wart remover country. Just how much “beta-hydroxyacid” do you think you need? You may want to pull back a bit.
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I’m making anti acne so I’m using 2%….so far I’ve been able to solubilize it in 15% propanediol with no recrystallization………..I’m thinking I should be able to use less propanediol, but I haven’t tried though
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I seem to recall it also dissolves in other polyols, such as glycerin, sorbitol, ethoxydiglycol, dipropylene glycol. Cannot remember the solubilty factors, sorry to say. Best yet is ethanol or phenoxyethanol - if you can stomach it. I also recall certain amphoterics like coco-betaine worked. Hope this helps.
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Matt, you would be surprised at what high % people want acids in facial peels these days.
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