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Sanitiser
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Here’s what the guide says:Hydrogen peroxide: used to inactivate contaminating bacterial spores in the solution and is not an active substance for hand antisepsisSo, if you remove the hydrogen peroxide, it won’t affect how well the sanitizers kills the viruses. However, hydrogen peroxide does act on bacterial spores in the sanitizer itself, and it is important to deactivate those so that you don’t catch a bacterial disease from it.
Hydrogen peroxide shouldn’t be hard to get, I would just add it if you can at all. If you really can’t, I would personally still use it, but that’s just me and not something I would suggest if you intend to sell it.
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I tried to make sample of gel sanitizer the lol is 🙂
Carbomer 996 : 0,5%
TEA : 0,5 %
IPA : 60%
EDTA : 0,1 %
Water: Qsp
The process put water, add Carbomer, neutralizer with TEA untill getting good gel, adding half amount of IPA was good when add all amount gel broke down, and I get precipitation of Carbomer, I add water to reduce the level of IPA and get gel but it did not work
So why even I reduce the level of IPA Lower then 60% I did not get gel?
Is there any solution to correct the sample? -
Have you tried 940?
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Before anyone else wastes materials that are expensive or might be hard to replace, from recent experience I have learned that Sepimax Zen works well with ethanol, or even a blend of 60 ethanol and 10 isopropyl to 70% by weight as close as I could calculate it, though Aristoflex AVC is more elegant feeling with if you’re using all ethanol. In the past I have typically used about 1-2% propylene glycol or propanediol and 2% isopropyl myristate with the gellants, alcohol(s), and water.However, neither Aristoflex AVC nor Zen is as accomodating with isopropyl at 70% volume or weight. The AVC refused to interact with the isopropyl alcohol. The Zen looked like it might work, but it stayed liquidy and then separate i blobs when I left it overnight. It was cloudy and once I poured off most of the isopropyl and added a bit of distilled water just to see what would happen, the Zen did gel or fully hydrate as expected. Lovely mass of mildly alcoholic smelling cloudy gel. Sepigel 305 didn’t work either, it blobbed into rubbery bits.To be fair, I’m only a hobbyist, so I might be doing it wrong.Since I don’t have any Ultrez 10 or 20 or carbopol 940 or high concentration ethanol, and only part of a liter of 91% isopropyl alcohol left, I decided to just buy some small spray bottles and live with liquid sanitizer.
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If the carbopols or ultrezes aren’t available, you can try Rheocare C plus from BASF @ 0.25% , and neutralise with AMP 95. This is for 65% Ethanol based.
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Using a homemade sanitizer is harmful
And can we use isopropyl9 -
Can anyone please help me about sanitizer ..as I m using carbopol and isopropyl9
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@rajastyle if you make gel sanitizer with minimum level 60% of alcohol it will be fine.
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justaerin said:Before anyone else wastes materials that are expensive or might be hard to replace, from recent experience I have learned that Sepimax Zen works well with ethanol, or even a blend of 60 ethanol and 10 isopropyl to 70% by weight as close as I could calculate it, though Aristoflex AVC is more elegant feeling with if you’re using all ethanol. In the past I have typically used about 1-2% propylene glycol or propanediol and 2% isopropyl myristate with the gellants, alcohol(s), and water.However, neither Aristoflex AVC nor Zen is as accomodating with isopropyl at 70% volume or weight. The AVC refused to interact with the isopropyl alcohol. The Zen looked like it might work, but it stayed liquidy and then separate i blobs when I left it overnight. It was cloudy and once I poured off most of the isopropyl and added a bit of distilled water just to see what would happen, the Zen did gel or fully hydrate as expected. Lovely mass of mildly alcoholic smelling cloudy gel. Sepigel 305 didn’t work either, it blobbed into rubbery bits.To be fair, I’m only a hobbyist, so I might be doing it wrong.Since I don’t have any Ultrez 10 or 20 or carbopol 940 or high concentration ethanol, and only part of a liter of 91% isopropyl alcohol left, I decided to just buy some small spray bottles and live with liquid sanitizer.
Sorry, do u mean the Seppimax Zen did work or didn’t. Also if it did do u know where to source, everywhere seems sold out.
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@crillz no problem. Sepimax Zen didn’t work with isopropyl at 70% for me. Zen did work with ~65-70% ethanol for me.All of the polymers that are known to work well with high amounts of alcohols are out of stock at the suppliers I’ve used.
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@justaerin why do you need 70% IPA anyway? You only need 60% w/w as per WHO.
And for ethanol, i guess you need 73.5% w/w. -
Trial goes Ok with ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER.with 0.4%.but troubling taking big batches. Gel not forming. after adding 40% IPA gel breakdown. is it because of IPA pH 5.5.does Quality of IPA effect? -
IPA grade matters. Some qualities are even alkaline though really pure IPA/water mixtures are pH neutral (pH 7).You always have to adjust pH with pH sensitive gellants. -
@Padmavathi I haven’t seen a 60% guideline for IPA from WHO, but I might have missed it. Everything I have seen from them, and from studies done on their handrub formulations, don’t suggest anything lower than 70% vol/vol for IPA.There is a new USP document that gives a formulation for a 60% v/v version made from 70% v/v IPA, but they don’t give any references for it and I don’t know if it has been tested.
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If you are going to attempt to make hand sanitizer, please follow the guidelines by the WHO.
https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf?ua=1Stay safe everyone.
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@Perry @Pharma.Thank you sir.
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@justaerin the WHO guideline i read said 75% v/v of IPA which is about 60% w/w.
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@Padmavathi 60 % w/w is far and lower then 75 % v/v .
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@Fekheri, density of IPA is 0.78509 . So that multiplied by 75 (ml) should give you the weight of it, which is 58.88 g. I Approximated it to 60.
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@Padmavathi with that calculation you just calculate grams of pure IPA For 75 ml. For passing from v/v to w/w make some reasearchement it is not as simple as you calculate.
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I’m getting better at this. Lubrizol 940 works perfectly well, I made a batch today using 0.4% carbomer and it was a little thicker than wanted, I suggest 0.35% if using 940. I added 0.1% lavender essential oil to help inhibit microbial spores since I have no H2O2 in stock. End result smelled good and looked slightly hazy.
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@Belassi You’re not going to kill spores with lavender EO. What you need is one or several of the following strategies:- Use another oxidising agent: Iodine or hypochlorit comes to mind- Cook the sh*ç@ out of your product (not to recommend with gels and alcoholic products, you know why better than I do :blush: )- Use sterile filtration (not easy with gels and doesn’t solve container contamination and the like)- Don’t care about spores (for more or less clean raw materials and GMP/GxP an acceptable decision)- Use an aldehyde: Formaldehyde and glutaraldehyde are common but require uncomfortably high levels to go from sporistatic to sporicidal. As an educated guess, aldehyde containing EOs might be an option (unfortunately, that includes several of those which have to be labelled due to allergic potential exactly due to presence of reactive aldehydes).The trick with spores is that they are very tough nuts to crack and require removal, heat (for some species even more than the product can take), or chemical reactions. Lavender EO contains mostly hydrocarbons as well as phenols and esters thereof which do not undergo necessary chemical reactions with spores. If you need inspiration which to choose, döTerra as an example has a list for possible candidates (first hit asking Google).BTW go somewhat acidic (alkaline would work too but destroys the skin acid mantle and that’s obviously bad, worse regarding the current situation).
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Just a bit of safety info on essential oils, particularly the highly allergenic cinnamaldehyde. At 1% concentration, 2% of patch tests showed a reaction, “this makes cinnamaldehyde the most high-risk essential oil constituent known from patch testing (Tisserand and Young 2014, p93).” The recommended maximum safe dilution of cinnamon bark oil is below 0.07%. I don’t know if that is high enough to do anything against spores though.
(Source: https://tisserandinstitute.org/new-survey-reveals-dangers-of-not-diluting-essential-oils/)Furthermore, since Ethanol enhances penetration, I would personally want to go even lower than that or avoid potential allergens altogether. Hydrogen peroxide is easy enough to buy, and by the way also very useful for surface disinfection if you don’t know what to do with the rest of the bottle. Just be sure to dilute appropriately and wear gloves… Ouch.
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I haven’t read all the posts and maybe someone already said it, but remove the water and I don’t see any point in adding aloe there.
PG is way too low. -
@Fekher okay i will check.
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