• Formulating

  Question about LMW Hyaluronic Acid

  Posted by Heath0o7 on April 15, 2024 at 10:01 pm

  Hi, <div>

  @Perry44 @OldPerry @Graillotion @Microformulation

  I’m planning on buying a LMW Hyaluronic Acid (0.4M-0.8M), but before I do. I wanted to know if this type of HA can penetrate the skin? I read that HMW HA stays on the surface of the skin, but I’m not sure whether LMW HA can penetrate the skin or does it have to be ultra low to do that?

  </div>

  fareloz replied 7 months ago 2 Members · 3 Replies

  • hyaluronic acid
  • skin
• 3 Replies

• 

  fareloz

  Member

  April 16, 2024 at 4:41 am

  The 500 Dalton Rule suggests that in order for a molecule to penetrate the skin barrier, its molecular weight must be less than 500 Daltons. All HA forms, even ultra small, are much bigger than 500 Daltons.

  Also, the smaller HA ingredient - the less potent it is in terms of binding water. If you need a good hydration - use Glycerin.

  • 

    Heath0o7

    Member

    April 17, 2024 at 6:11 am

    @fareloz thank you for the clarification!

    Just out of curiosity, would there be a way for HA to penetrate deep into the skin? Like using an enhancer, or there’s just no way for it to penetrate no matter what

    • 

      fareloz

      Member

      April 17, 2024 at 6:38 am

      Of course there is a very popular way - injections.

      In terms of skincare - you are not allowed to “penetrate deep”. Skincare is not a drug, it should stay at upper layers of the skin

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