Home Cosmetic Science Talk Formulating povidone iodine 10% solution for wounds

  • povidone iodine 10% solution for wounds

    Posted by AndrewSeel on February 5, 2018 at 10:28 pm

    Hello There, I am a pharmacist and i intend to start small business to produce some products,  one of them is Povidone Iodine 10 % solution - equal to BETADINE, I found this formula but it is not for industrial purposes as i think, it has a short shelf life about 3 months and not economically effective, Any body Can help by advise regard the formula??
    I used : 

    Povidone
    iodine powder

    110 g

    Sodium
    dihydrogen phosphate anhydrous

    13.6 g

    Citric
    acid monohydrate

    8.8 g

    Water

    to 1000 ml

    em88 replied 6 years, 10 months ago 6 Members · 13 Replies
  • 13 Replies
  • belassi

    Member
    February 5, 2018 at 11:28 pm

    Well, what is the Betadine LOI? There’s your start point.

  • AndrewSeel

    Member
    February 6, 2018 at 9:18 am

    Betadine is povidone iodine solution 10%

  • em88

    Member
    February 6, 2018 at 2:47 pm

    As Belassi suggested, you should find some product references and check the list of ingredients (LOI).
    Here is what I found:
    Excipients: glycerol (glycerin), nonoxynol 9, citric acid anhydrous, disodium hydrogen phosphate, sodium hydroxide 10% solution (w / v) (for pH adjustment), purified water. 

  • zaidjeber

    Member
    February 7, 2018 at 2:27 am

    Easy, you can find the LOI and mixing procedure in practical pharmacology book of the 3rd year of any medical college.

  • belassi

    Member
    February 7, 2018 at 3:10 am

    Talking about iodine. They painted me with some weird stuff when I was in the Cath Lab. After, I couldn’t get it off for days and days. It was like a brown film stuck on to my skin, obviously contained iodine. They paint most of the patient with it during major surgery.

  • zaidjeber

    Member
    February 7, 2018 at 4:04 am

    @Belassi that is 3MDuraPrep antiseptic surgical solution, its usually used to sterilize the surgical site, mainly skin. As you described, its creates a water resistant and wash off resistant film that can last for 2-3 days. 

  • Duncan

    Member
    February 7, 2018 at 11:54 pm

    Isn’t that stuff povidone iodine and PVA?

  • Duncan

    Member
    February 7, 2018 at 11:55 pm

    or even PVP

  • Doreen

    Member
    February 9, 2018 at 4:21 pm

    It’s not really clear to me what kind of help you need?

  • AndrewSeel

    Member
    February 10, 2018 at 7:14 pm

    My friend Zaidjeber, in pharmaceutical book it is merely a formula for lab practice not industrial formulation. Do you have any recommendations?
    Belassi you are right. I think the formula may contain xanthan gum so it will form a film on skin.
    Duncan yes  it is.
    Doreen81 what i need to know is how to convert this lab formula to an economical long shelf life formula, especially it is for wound disinfection purposes.
    So guys how doyou suggest to proceed?

  • belassi

    Member
    February 10, 2018 at 9:20 pm

    Just for starters I doubt the formula you presented. It contains no alcohol. I don’t believe iodine is water-soluble. The stuff they painted me with was freezing cold, evaporated very fast, and I could smell the ethyl alcohol. 

  • zaidjeber

    Member
    February 12, 2018 at 8:00 am
  • em88

    Member
    February 12, 2018 at 8:12 am

    povidone iodine is water soluble 

Log in to reply.

Chemists Corner