Piroctone Olamine... how to dissolve it?

Tagged: shampoo-antidandruff-piroctoneolamine

Formulating

Piroctone Olamine… how to dissolve it?

Posted by Clondono on October 10, 2022 at 3:25 pm

Hi.

I am currently working on an antidandruff shampoo formula and I want to use Piroctone Olamine (0.75%) but it has been difficult to dissolve it. I did some research and found that it is soluble in surfactant solutions, but I tried to do it and it is not working. The surfactants I am using are Sodium Laureth Sulfate, Cocamidopropyl Betaine and Cocamide DEA. As well, I am using Polysorbate 80 to solve some oils and I even notice that it makes the precipipate more noticeable. Thanks in advance!!

PhilGeis replied 2 years, 1 month ago 4 Members · 11 Replies
- shampoo-antidandruff-piroctoneolamine
11 Replies

PhilGeis

Member
October 10, 2022 at 7:21 pm

As the objective is to deposit the stuff on the scalp - are you sure you want a solution?
Clondono

Member
October 10, 2022 at 9:46 pm

PhilGeis said:

As the objective is to deposit the stuff on the scalp - are you sure you want a solution?

I want an homogenous shampoo.
Abdullah

Member
October 11, 2022 at 1:26 am

What is your formula?
Abdullah

Member
October 11, 2022 at 7:33 am

PhilGeis said:

As the objective is to deposit the stuff on the scalp - are you sure you want a solution?

@PhilGeis if it is a leave on scalp product, does it matter if Piroctone Olamine or another active is in solution form?
PhilGeis

Member
October 11, 2022 at 10:12 am

Deposition is the objective - from solution or suspension. Do not know why a solution is required to achieve a homogenous product.
Clondono

Member
October 11, 2022 at 11:44 am

Abdullah said:

PhilGeis said:

As the objective is to deposit the stuff on the scalp - are you sure you want a solution?

@PhilGeis if it is a leave on scalp product, does it matter if Piroctone Olamine or another active is in solution form?

It is not a leave on product… it is a shampoo.
Clondono

Member
October 11, 2022 at 11:47 am

PhilGeis said:

Deposition is the objective - from solution or suspension. Do not know why a solution is required to achieve a homogenous product.

PhilGeis said:

Deposition is the objective - from solution or suspension. Do not know why a solution is required to achieve a homogenous product.

I don’t mind if my formula is cloudy. I just want piroctone olamine to be well mixed and homogenous in my shampoo.
PhilGeis

Member
October 11, 2022 at 3:31 pm

You may be oversimplifying.
How do you expect to ensure the product works? It is not sufficient to formulate with an active - enough active has to be deposited with enough coverage to be effective.
Assume you’re not in the US.
Clondono

Member
October 11, 2022 at 9:26 pm

PhilGeis said:

You may be oversimplifying.
How do you expect to ensure the product works? It is not sufficient to formulate with an active - enough active has to be deposited with enough coverage to be effective.
Assume you’re not in the US.

Yes, I think I get it… I must be looking for coarcevation instead of solution, right? Thanks so much. I’ll try to do that instead.
suswang8

Member
October 12, 2022 at 3:45 am

I would love to find out the answer to this, as I wasn’t able to get it to “hold” in ethanol (as part of a scalp solution I was trying to make). Contacting the supplier didn’t help other than their suggestion to add it too a pre-formulated shampoo. That worked, but I would still like to get an answer to my original question.
PhilGeis

Member
October 12, 2022 at 10:54 am

Should be soluble in aq alcohol (~10%) solution. pH should be around neutral to sl alkaline.

Piroctone Olamine… how to dissolve it?