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Mouthwash
Hi all
We are making mouthwash with using standard ingredients, as Aloe Vera Gel, Sodium Fluoride, Sodium Saccharine, Sodium Benzoate, Cetylpyridinium Chloride, Allantoin, Colour, Flavour, Polysorbate20. Product is clear when made. After a couple of months we get fall out with white flaky powder in the product. once shaken this goes back in and stays suspended for a few weeks. Any ideas why we get fall out? -
19 Replies
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You can either isolate and analyse the precipitate using the usual methods, or perform knock-out tests on the likely culprits.
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@Belassi Can I have more info please?
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Well it really depends on your lab equipment and expertise. The simplest way is knock out tests, this is not really an area with which I have any expertise. Is sodium fluoride very soluble or not? Cetylpyridinium Chloride? I don’t use such as these. Sorry I can’t be more helpful, I’m sure there are people here who can offer better advice.
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What is the allantoin level?
What is the purpose of the aloe vera? -
This is so recognizable that I have to mention it: I have the same problem with adding allantoïn (0,5-0,7%) to a (clear) aloë vera toner. In my case it happens already after a month or so, shake it, clear again.
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Allantoin solubility (seems to fit @AnnaLavar s problem)
Solvents
T (°C)
%
Water
25°C
0.5
Water
40°C
1
Water
70°C
3.5
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@David, thanks!
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@johnb we use allantoin @ 0.01%. |It protects the oral mucosa and acts as an anti-irritant. It also promotes the healing of lesions.
@Belassi Cetylpyridinium chloride is an antiseptic which kills bacteria and maintains your oral hygiene. Is widely used in mouthwash because it is very effective in preventing dental plaque and it is also very helpful to reduce gingivitis.
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is it true that Sodium benzoate requires acidic conditions?
pH of the product we make is between 6.0-7.0 -
@marek.barnas it is true; sodium benzoate is completely ineffective above pH 5
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@Bill_Toge what other preservative can be used in mouthwash please?
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the main ones apart from sodium benzoate are sodium methyl paraben, and propylene / butylene glycol
bronopol used to be used a lot, but not so much these days as it causes the product to go yellow over time
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@Bill_Toge I thought that Butylene Glycol is a solubilizer
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Can sodium benzoate create a soapy taste? or is it something to do with Polysorbate 20?
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Most likely the polysorbate that is giving the soapy taste. Sodium benzoate is just slightly bitter and at normally used concentrations in soft drinks/mouthwash and so on it is non-detectable.
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@marek.barnas 1,2-diols (of which propylene and butylene glycol are examples) have antimicrobial effects; the activity increases as the chain length increases
unfortunately, as the chain length increases, solubility decreases and the taste becomes much more unpleasant
they can act as solubilisers as well - the effects are not mutually exclusive
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Allantoin can cause such problems because of its solubility. Try to add Glycerine or Propylene glycol to solubilize Allantoin. Also check your water quality. any kind of hardness can cause such problems. Glycerine also gives a sweet taste also. Disolve allontoin in solvents first.
Regards -
hasanarsan
This query was left in the charge of the originator to reply. There is little for anyone to do until that happens.
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I agree with hasanarsan, the problem could be alantoin, because its solubilty is very low in water. My advice is do the formulating with out the alantoin and put in the fridge (4°C) in 48 hour you can have results.
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