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Mixing hydrophilic + hydrophobic materials for topical
What would be the least ingredients needed for a viable formulation (deep penetration) if my supply is limited to:
Objective: Mix polyphenol (hydrophobic) + antioxidant (hydrophilic) +
Mango butter (or Cocoa butter)Hydrophobic compound mixes very well with Mango butter. Antioxidant I dissolve in distilled water. I try adding Ethanol or Propylene glycol, even try a powerful homogenizer, but the mixture does not mix too well.
Other material available: Polysorbate 80 and cooking oils (like olive oil, MCT etc).
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3 Replies
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I am not sure if I understand properly.
Are you looking for an emulsifier? Essentially you cannot mix hydrophilic and hydrophobic ingredients without something that will hold them together.Polysorbate 80 could help, but only to, more or less, solubilise some of the lipid into water.
PS. What hydrophilic antioxidant do you have?
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You need a surfactant/s based on HLB of hydrophobic polyphenol? to blend into emulsion with water phase containing the soluble hydrophilic ingredientsPolysorbate 80 HLB with HLB of 15 may be too high.
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This might come across as offensive, before you drive deep into penetration enhancing, I recon you start with basic cosmetics formulation.
Perry offers a course here that cover most if not all the things for beginner.
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