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Lauric acid in a topical? Good or bad idea for acneic skin
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No offense taken, there are references in the wiki article, but looking at them they might not answer the specific question of p.acnes skin surface vs follicle/dermis population. I looked around for a bit and haven’t seen any papers looking into it.
The commonly used comedogenicity index could be useless, or it could be useful, we don’t know, in any case It’s a bit suspicious that there are no human follow up studies.
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There is really only one definitive way to know: Formulate a product with either Lauric Acid or Glyceryl Laurate and test it on humans who have acne-prone skin.
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I agree with you. You bring up a very interesting question as I saw in one published paper wherein the results showed that Lauric Acid reduced the P. Acnes population by 15X compared to Benzoyl Peroxide.Unfortunately, there is scant published evidence on human studies regarding comedogenicity … I suspect that is because it is quite pricey to do those studies.Since the FDA Acne OTC monograph only allows the 4 approved ingredients for one to be able to make acne product claims, it might be interesting to combine Lauric Acid or Monolaurin with a touch of Salicylic Acid in an acne formulation.Assuming you are in the US?
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For non-controversial topics Wikipedia is actually a decent resource. It’s been shown to be as reliable as something like encyclopedia Britannica.
Although it’s more of a starting point than an ending point. -
Greetings. I’m glad someone’s talking about this. I have just created a prototype formula containing solid lipid nanoparticles of lauric acid. This is heading into the hands of a local dermatologist’s patients very soon. I will report the results on this site.
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