• Formulating

  Lactic Acid Stability

  Posted by Anonymous on April 25, 2019 at 3:39 pm

  I am having issue with the Lactic acid during stability study. While running the HPLC method %LA tends to increase in the 40C sample (sometimes out of spec). Is this normal? Is there any other method to test for LA in a formula that has multiple acids?   

  Bill_Toge replied 5 years, 7 months ago 1 Member · 1 Reply

  • lactic acid
  • stability testing
• 1 Reply

• 

  Bill_Toge

  Member

  April 25, 2019 at 6:56 pm

  the most likely explanation is that water is evaporating from the 40 °C sample over time, causing the percentage of lactic acid relative to the whole formula to increase

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