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Issue With Xanthan Gum / Hydroxyethylcellulose Precipitating from Aqueous Serums
I’m having a bit an issue with with a mixture of Xanthan Gum & Hydroxyethylcellulose precipitating from solution in low pH aqueous serums. Anyone have any ideas?
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6 Replies
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I am homogenizing at 15,000 RPM for 10 minutes, stirring for 30 minutes, and homogenizing at 15,000 RPM for another 10 minutes. The solution is relatively clear. But, in doing stability testing, I am getting some settling of a “gel” after 2 to 3 weeks and/or a floating haze, with a very clear layer at the top.
I’m going to do a run without the gums to see and a separate run with the gums to make sure that the precipitate is the gums or not. -
You might also try an experiment where you adjust the pH higher to see if that is causing the problem.
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Yes, I suspect it is indeed a pH issue as I get more precipitate with one formulation at pH 3.5 than I get in a second formulation at pH 4.0.
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I think the culprit is Hydrolysed Wheat Protein … anyone ever have issues with Hydrolysed Wheat Proteins precipitation out at low pH?
I did a knock-out experiment eliminating the Hydrolysed Wheat Protein and that seems to have done the trick. -
Hi Mark,
I think you should reduce the time & speed of homogenizer, sometimes due to high speed & prolong homogenizing creates separation.
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Thanks Alam. I will give that a try. Appreciate it!
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