Hyaluronic acid separation - Chemists Corner

Formulating

Hyaluronic acid separation

Posted by Rana_91 on October 3, 2024 at 7:23 pm

Hi

Iam making a facial cleanser for dry skin

The formula

Decyl glycoside 10%

Betaine 5%

Caprylic triglyceride 3% with polysorbate 3%

Ceramide 0.5%

Glycerin 5%

Probylene glycol 5%

Germall 0.5%

EDTA 0.5%

Hyaluronic acid 0.2%

The problem is that hyaluronic acid keeps separating from the formula.. i tried high sheer mixer to blend it in but it didn’t work

Any suggestions

Fekher replied 3 months, 3 weeks ago 6 Members · 11 Replies
11 Replies

jemolian

Member
October 3, 2024 at 7:38 pm

What are the steps and phases?
- Rana_91
  
  Member
  October 3, 2024 at 7:42 pm
  
  Adding glycerin to polyquatrinum 10 with water until dissolved
  
  Then adding decyl glycoside with betaine and adding lactic acid to adjust ph
  
  Then ceramide and germall, EDTA
  
  Then caprylic with polysorbate 20
  
  Finally hyaluronic acid dissolved in water
  - jemolian
    
    Member
    October 3, 2024 at 8:05 pm
    
    Did you continue stirring while the hyaluronic acid hydrates? Just wondering about that.
    - Rana_91
      
      Member
      October 4, 2024 at 7:56 am
      
      I added it after i dissolved it in water and blended with high sheer mixer
MarkBroussard

Professional Chemist / Formulator
October 3, 2024 at 9:21 pm

@Rana_91

What molecular weight HA are you using? This will probably work with a HA < 50 kDa, but not with higher mw HA
- Rana_91
  
  Member
  October 4, 2024 at 8:02 am
  
  Its low MW .. iam not sure how much in specific
  
  Will it be better if i add it to polyquatrinum from the start ??
ketchito

Member
October 4, 2024 at 8:52 am

Did you do a knockout test, just to confirm it’s the HA?
- Rana_91
  
  Member
  October 4, 2024 at 1:37 pm
  
  No … Can you help me how to do it ??
- Rana_91
  
  Member
  October 4, 2024 at 3:50 pm
  
  I read about it .. i did it and it was the hyaluronic acid that separated
zeyneb-chem

Professional Chemist / Formulator
November 3, 2024 at 7:18 am
hi, i had the same problem before,,i don’t know why but polyquaternium 10 isn’t compatible with hyaluronique acid in free sulfate products, so u have an ingredients is not compatible with hyaluronic acid
- This reply was modified 3 months, 3 weeks ago by zeyneb-chem.
Fekher

Professional Chemist / Formulator
November 3, 2024 at 11:08 am

What is the benefit of using caprylic capric triglycerides in facial cleanser?

I find it both:wasting of money with decreasing the effeciency of the cleanser.