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Gel based Hand sanitizer
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We are a pharmaceutical industry with GMP and the supplier of ethanol is certified as well. We also test the purity of ethanol. The concentration is 96%.
What does lubrizol say? And by the way, we work only with lubrizol. -
@em88 that what Lubrizol Said.
So do you think that Lubrizol can be wrong?!
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Oh, now I see. I remember that paper.
Well, have you tried any of those formulations?
I have tried a few of them, as I remember not all the data presented there did match with my results. To be fair, this is normal. It happens many times from different manufacturers. I believe those data are to create an idea about the performance of their products and the difference between neutralizers. Also in that particular table, it is not mentioned what carbomer did they use. -
I find I can make 63% ethanol gel using TEA to neutralise.
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Hi all,
May I know the reason behind the precipitation of TEA when we used alcohol above 60% ? And why AMP does not ppt out and give clear gel. -
At a guess, this:
Carbomer as I understand it, is acrylic acid. So when you neutralise it, you get a salt. In the case of the different bases, you’ll get, for instance, sodium acylate, potassium acrylate, and someone else will have to tell me what the rest are. And each salt will have a different solubility in alcohol. -
Belassi said:At a guess, this:
Carbomer as I understand it, is acrylic acid. So when you neutralise it, you get a salt. In the case of the different bases, you’ll get, for instance, sodium acylate, potassium acrylate, and someone else will have to tell me what the rest are. And each salt will have a different solubility in alcohol.That’s indeed the reason why.
Na, K salts are very water soluble but not too alcohol soluble, hence the need to use “exotic” neutralizers.Salts are usually much less soluble in IPA than in ethanol.
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Is there any temperature dependency with the mixing of carbopol? Like if I mix any carbopol grade with chilled water having temperature around 5-10C, will it dissolve properly or form lumps?
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em88 said:I wrote the steps above. We registered a product with 70% m/m ethanol already.
Maybe you are looking for high viscosity gels? For me 6000-10000 cP is enough for a hand sanitizer.Hello, can you say how much triethanolamine do you use?
I am using 0.35% carbopol 940.
When I add 0.17% triethanolamine, in the last half, it forms a milky mixture and it losses all viscosity.
I am concerned that this happens because I only have 20% m/m of water.
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joanaflores said:em88 said:I wrote the steps above. We registered a product with 70% m/m ethanol already.
Maybe you are looking for high viscosity gels? For me 6000-10000 cP is enough for a hand sanitizer.Hello, can you say how much triethanolamine do you use?
I am using 0.35% carbopol 940.
When I add 0.17% triethanolamine, in the last half, it forms a milky mixture and it losses all viscosity.
I am concerned that this happens because I only have 20% m/m of water.
May I ask what alcohol are you using? ethyl or isopropyl
What’s the alcohol concentration in the gel?I’m asking you because you can only make up to 60% alcohol using TEA (and that with Carbopol Ultrez, I don’t know if that works with 940)
To get beyond 60% alcohol, you’ll need some other neutralizers as stated in the Lubrizol document: Neutralizing Carbopol and Pemulen in Aqueous Hydroalcoholic Systems.
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joanaflores said:em88 said:I wrote the steps above. We registered a product with 70% m/m ethanol already.
Maybe you are looking for high viscosity gels? For me 6000-10000 cP is enough for a hand sanitizer.Hello, can you say how much triethanolamine do you use?
I am using 0.35% carbopol 940.
When I add 0.17% triethanolamine, in the last half, it forms a milky mixture and it losses all viscosity.
I am concerned that this happens because I only have 20% m/m of water.
I have worked with carbomer 940 very long time ago and I don’t remember the concentration of triethanolamine. At the moment we work only with carbomer 980. For this type of carbomer we use about 0.1% of triethanolamine. You should check the pH of the gel and be in the range of 6-7. Use a low mixing speed when neutralizing.
I’d recommend you to use 0.4-0.5% carbomer.
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