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Does this come from a human?
OK, this might be the dumbest question ever to be asked on Chemists Corner, but here goes… I have been looking for a vegan, cruelty-free and palm oil-free Collagen and I think I have found one. It’s this:
Col-Frag by Lipotrue
INCI: Glycerin, Water, Pentylene Glycol, Collagen
Amino Acid.I have read the information booklet and this is the bit that worries me:
Fragment of human type I collagen (100 aa).
What does that actually mean? It sounds like it comes from a human.. but.. surely not? Either way, one of my customers will ask, so I thought it best to ask you guys. Does anybody know? Thanks.
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7 Replies
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https://www.ulprospector.com/documents/1620326.pdf?bs=34061&b=4705175&st=1&sl=117260687&crit=a2V5d29yZDpbQ29sLUZyYWdd&k=Col-Frag&r=asia&ind=personalcare
https://www.ulprospector.com/documents/1620328.pdf?bs=34061&b=4705175&st=1&sl=117260687&crit=a2V5d29yZDpbQ29sLUZyYWdd&k=Col-Frag&r=asia&ind=personalcarethey mention their collagen fragment from wild plant Nicotiana Benthamiana
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If I remember correctly, genetically modified Nicotiana sp. are used to express several foreign proteins and peptides. When I first read about this I was WTF… I have no clue why Nicotiana and not microbes which are usually used for this kind of work.
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But why do they call it ‘Fragment of Human Type I Collagen’ if it’s from a plant?
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That’s probably because this ingredient may have a peptide sequence that is very similar to, or the same as, the peptide sequence found in a particular fragment of Human Type 1 Collagen and it makes a compelling marketing story
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@MarkBroussard OK thanks, that makes sense. I had to be sure. My brand is vegan and I have been having an existential crisis over whether something of human origin makes us no longer vegan, ha ha!
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SugarHouse said:But why do they call it ‘Fragment of Human Type I Collagen’ if it’s from a plant?GMO: You take the DNA sequence for example of a part of human type I collagen and implant that into tobacco cells.So… given that vegan is more of a label and a pilosophy than ‘noting from animals’ let alone ‘what’s best for nature and the planet’, it’s your decision whether or not you want to use it. Given the not always logical restrictions of veganism, using GMO of the type where hydroponically grown plants were violated against their will to express proteins of their archenemy could absolutely be okay. It’s just a plant which does weird things it could naturally never do.
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If the peptides are actually synthesized by the plant - https://pubmed.ncbi.nlm.nih.gov/23252967/.
Why are you using it if it causes such angst?
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