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Colloidal Oatmeal in Dermatological Product Question
Hi, I am wondering if someone knows of a method to measure colloidal oatmeal and its stability in a topical dermatological product? Thanks in advance!
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11 Replies
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You asked this same question earlier today.
You would be best asking the supplier of the material for their test methods.
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Hi, thanks for the feedback.
Sorry about the double post, i thought the different categories were different discussions. -
I have actually already checked with two suppliers. No
real help.. as the methods to test raw material are not the same for a final
product. -
I’m somewhat doubtful if anyone carries out a detailed analysis for oatmeal content in cosmetics.
In pharmaceuticals, again I’m doubtful that minor variations in a relatively inert ingredient is of much import but you could analyse the product for starch content and estimate the oatmeal content by comparison.
There are established methods for starch analysis as you are no doubt aware.
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Do you mind telling me what you use the oatmeal for?
I’ve had good results with Grahams (2,5% oatmeal) when I had an allergic outbreak, which is the reason I’ve started using oatmeal myself.
I found a supplier selling the oatmeal kernel extract, which I hope is less sensitive to contamination and contains more avenathramide.Good luck for finding methods for analysis in your product btw.
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Thank you for the responses.
Concerning the starch - Total starch content may not be stability-indicating. Any suggestions for specific oatmeal markers? Thank you. -
The difficulty with what you’re asking is that oatmeal is a complex natural
mixture and it is thus almost impossible determine oat content in the presence of numerous other components in a mixture. I have offered an idea of determining oats based on the comparison of the starch content in product against starch in the original oat material. I really can’t see any other viable methods of determination. Measuring avenanthramides is not practical and still wouldn’t offer anything over measuring starch - perhaps even less due to greater precision necessary for detecting such minor amounts and the question of is an avenanthramide less stable than starch in the product being examined. -
Thank you @johnb, this is exactly the difficulty I am facing at this point.
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@Skincare_developer:
Your best approach would be to do an assay on specific components in colloidal oatmeal that you think are most relevant in dermatological activity: Beta-Glucan and a marker for avenathramide. There are several labs that specialize in assay analysis of actives in OTC and pharmaceutical products. Since, as johnb points out, colloidal oatmeal is a complex of several components, that may be your best approach.
Are you seeking to do this because Colloidal Oatmeal is listed as an Active Ingredient on an OTC or prescription drug product that you’re developing?
Perhaps you should contact the FDA for guidance on what they require in actives assays on products containing colloidal oatmeal as the active ingredient.
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Thank you. We are aware that
colloidal oatmeal is complex and that we should use one of its specific
components. Do you happen to know a lab that has experience in testing colloidal oatmeal
as an active ingredient in OTC products?What is that path of contacting
FDA for specific guidance?Thanks in advance!
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@Skincare_developer:
Sorry, I do not know of a lab to refer you to that has specific experience in colloidal oatmeal, but any lab that does pharmaceutical actives assays should be able to work with oatmeal.
Just call the FDA … they can be quite helpful and will guide you in the right direction.
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