Home Cosmetic Science Talk Formulating Cetyl alcohol as a comedogenic modifier?

  • Cetyl alcohol as a comedogenic modifier?

    Posted by Graillotion on December 5, 2022 at 8:18 pm

    This morning’s read took me to this article ( @chemicalmatt;) .  I thought I was reasonably up on the topic of comedogenics, but when I dusted off the memory banks…., I could not recall hearing that cetyl alcohol was a comedogenic reducing agent.

    If any of you ‘sharper knives in the drawer’, have the time….I would love to hear an extrapolation on this possible concept (mode of action).  I will paste an illustration from the article…and the article.  Maybe this is just internet lore?

    BTW….I am fully aware most of these rating being scored at 100% strength and the minimal effect especially when in formula at low rates.  Don’t need that lecture.  :D 

    Comedogenic ingredients with a grain of salt (be-smooth.com)

    Table 8: Lactates
    Myristyl lactate is a relatively severe comedogenic ingredient used commonly in moisturisers and sunscreens. Its dilution to 50% in a propylene glycol base will not reduce its comedogenic score. However, when combined with cetyl alcohol, the severity of any reaction is significantly reduced.

    Chemical Rating /score
    Myristyl lactate 100% 2-3/3, 3/4
    Myristyl lactate, 50% in propylene glycol 2-3/3
    Myristyl lactate, 50% in cetyl alcohol 0-1/4
    ketchito replied 2 years ago 4 Members · 6 Replies
  • 6 Replies
  • Paprik

    Member
    December 5, 2022 at 11:21 pm

    Oh, sorry @Graillotion for this a bit off topic comment, but I just learned that Myristyl Myristate (which was recommended by many of you and I got it and use it) have rating of 5!! Shocking! Well, I do use it only at 1%, so should not be a problem, but still - Shocking :D 

  • Graillotion

    Member
    December 6, 2022 at 1:48 am

    Paprik said:

    Oh, sorry @Graillotion for this a bit off topic comment, but I just learned that Myristyl Myristate (which was recommended by many of you and I got it and use it) have rating of 5!! Shocking! Well, I do use it only at 1%, so should not be a problem, but still - Shocking :D 

    Yes…If I recall…it has a rating of 0 …. at that level.  Some ingredients are quite remarkable….the scare tactics used, and what their actual levels are….when used in formula.

    Mommy bloggers would have very little to fret about…if we took away comedogenic ratings from them.  :D

  • ketchito

    Member
    December 6, 2022 at 10:02 pm

    @Graillotion Funny thing that a client recently patch tested the following:

    - Shampoo w/fragrance 1
    - Shampoo w/fragrance 2
    - Conditioner w/fragrance 1
    - Conditioner w/fragrance 2

    Both shampoos and conditioners share the same formula (except for the fragrances)…and both shampoos were slightly irritant (irritation index around 0.21) while both conditioners were not irritants at all (irritation index about 0). So, same fragrances but different carriers (patch tests diluted at 2% -both shampoos and conditioners, but separately and with different subjects-). Maybe P&G was right about adding Cetyl alcohol to all their shampoos after all. 

  • Graillotion

    Member
    December 7, 2022 at 12:57 am

    ketchito said:

    @Graillotion Funny thing that a client recently patch tested the following:

    - Shampoo w/fragrance 1
    - Shampoo w/fragrance 2
    - Conditioner w/fragrance 1
    - Conditioner w/fragrance 2

    Both shampoos and conditioners share the same formula (except for the fragrances)…and both shampoos were slightly irritant (irritation index around 0.21) while both conditioners were not irritants at all (irritation index about 0). So, same fragrances but different carriers (patch tests diluted at 2% -both shampoos and conditioners, but separately and with different subjects-). Maybe P&G was right about adding Cetyl alcohol to all their shampoos after all. 

    Do I understand you correct….the conditions contain cetyl alcohol?

  • Abdullah

    Member
    December 7, 2022 at 2:18 am

    ketchito said:

    @Graillotion Funny thing that a client recently patch tested the following:

    - Shampoo w/fragrance 1
    - Shampoo w/fragrance 2
    - Conditioner w/fragrance 1
    - Conditioner w/fragrance 2

    Both shampoos and conditioners share the same formula (except for the fragrances)…and both shampoos were slightly irritant (irritation index around 0.21) while both conditioners were not irritants at all (irritation index about 0). So, same fragrances but different carriers (patch tests diluted at 2% -both shampoos and conditioners, but separately and with different subjects-). Maybe P&G was right about adding Cetyl alcohol to all their shampoos after all. 

    In my experience too 550 ppm formaldehyde as formalin in Shampoo was irritating to scalp but in a lotion it was not irritating to skin.

  • ketchito

    Member
    December 7, 2022 at 11:12 am

    ketchito said:

    @Graillotion Funny thing that a client recently patch tested the following:

    - Shampoo w/fragrance 1
    - Shampoo w/fragrance 2
    - Conditioner w/fragrance 1
    - Conditioner w/fragrance 2

    Both shampoos and conditioners share the same formula (except for the fragrances)…and both shampoos were slightly irritant (irritation index around 0.21) while both conditioners were not irritants at all (irritation index about 0). So, same fragrances but different carriers (patch tests diluted at 2% -both shampoos and conditioners, but separately and with different subjects-). Maybe P&G was right about adding Cetyl alcohol to all their shampoos after all. 

    Do I understand you correct….the conditions contain cetyl alcohol?

    @Graillotion Yes. The conditioners contain both Cetyl and Stearyl alcohol. 

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