Home Cosmetic Science Talk Formulating Can we trust chatGPT or my questioning method is not correct?

  • Can we trust chatGPT or my questioning method is not correct?

    Posted by Abdullah on February 19, 2025 at 2:47 am

    Can we trust chatGPT or my questioning method is not correct? <div>

    My question: What percentage of people can be sensitized by 3ppm CMI

    chatGPT answer: Research findings: At 3 ppm, sensitization rates vary widely, but reports suggest that around 5-10% of individuals may become sensitized at this concentration.

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    Abdullah replied 23 hours, 48 minutes ago 4 Members · 5 Replies
  • 5 Replies
  • ketchito

    Member
    February 19, 2025 at 7:05 am

    Keep in mind that ChatGPT only has access to abstracts or open access journals, while leaving many out, so there’s some bias (access bias?) to its answer. I’d feel more comfortable checking EU opinión on the topic, or CIR review.

  • Perry44

    Professional Chemist / Formulator
    February 19, 2025 at 7:13 am

    ChatGPT is not 100% reliable so you can’t trust it 100%. Although people are also not 100% reliable so it’s probably on par with most people you’ll ask.

    For this question, you should also ask ChatGPT to “list it’s sources” and then double check the source to see if it is accurately reporting

    Here’s what Perplexity says. It sounds more reasonable than what ChatGPT says.

    —————-

    Based on the available search results, there is no specific information about the percentage of people that can be sensitized by 3 ppm of CMI (chloromethylisothiazolinone). However, we can draw some relevant insights from the data provided:

    1. A skin sensitization study found that some leave-on products with MCI/MI (a mixture of methylchloroisothiazolinone and methylisothiazolinone) at 7.5 ppm may increase the risk of sensitization induction 3
      .
    2. Rinse-off products with 15 ppm MCI/MI were not associated with a potential increased risk of skin sensitization induction 3
      .
    3. In a Swedish baseline patch test study from 2003 to 2012, 3.1% of patients reacted to 200 ppm MCI/MI (3:1 ratio) 3
      .
    4. A more recent study using 2000 ppm patch test allergen showed an increase in positive results over time, with the highest prevalence in 2015 at 9.41% for MCI/MI 5

    Given that these studies used higher concentrations than 3 ppm, it’s likely that the percentage of people sensitized by 3 ppm CMI would be lower than the percentages reported in these studies. However, without specific data on 3 ppm CMI sensitization, it’s not possible to provide an exact percentage.

    • This reply was modified 2 days, 1 hour ago by  Perry44.
  • Abdullah

    Entrepreneur
    February 20, 2025 at 1:37 am

    @ketchito @Perry44 that

    I was just testing chatGPT.

    I did use Perplexity for only 10 minutes now and i like it more than chatGPT.

    One question about these studies.

    Why don’t they study sensitization rate of the upper limit of preservatives like 15ppm & 7.5ppm CMI MI instead of 200 and 2000ppm?

    No one uses that high amount so no benefit of knowing what does that high amount do.

    • fareloz

      Member
      February 20, 2025 at 2:47 am

      Perplexity doesn’t generate own answers, it summarizes google search with AI. You can do it with OpenAI’s ChatGpt too, just enable “Search” mode.

      • Abdullah

        Entrepreneur
        February 20, 2025 at 9:11 am

        Thanks

        From where chatGPT answers without search mode?

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