Home Cosmetic Science Talk Formulating Advanced Questions Advice for working with Resveratrol?

  • Advice for working with Resveratrol?

    Posted by suswang8 on October 20, 2020 at 5:31 pm
    Hi, all.

    I have seen some conflicting information online about how best to work with resveratrol as part of an emulsion and wanted your advice, please.

    -1-  I believe some comments on here indicated that it should be added into the oil phase.  Is that correct?  If so, it would be solubilized into what exactly?  (I’m asking because I believe resveratrol is not oil-soluble.)
    -2-  I have seen elsewhere online that a better option might be to disperse it into glycerin (?) and then add this into the cool-down phase, perhaps because of heat sensitivity?
    Thank you.
    (Note:  I attempted to add this question into one of the older discussions about resveratrol, but was unable to do so.)
    Pattsi replied 4 years, 1 month ago 6 Members · 7 Replies
  • 7 Replies
  • OldPerry

    Member
    October 20, 2020 at 6:04 pm

    It is not soluble in water. The best solvent for it is PEG400.  See this paper.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427559/

    I don’t think the glycerin technique will help but I haven’t tried it. 

    Resveratrol has a melting point ~260C, it is not heat sensitive.

  • belassi

    Member
    October 20, 2020 at 8:38 pm

    Advice? Sure. Don’t waste your time.

  • ngarayeva001

    Member
    October 20, 2020 at 10:24 pm

    Not commenting on its skin benefits because papers I saw weren’t persuasive, but I managed to dissolve 4% in plain propylene glycol. It took an hour of stirring using a magnetic stirrer. Didn’t even had to heat it.

  • Pattsi

    Member
    October 21, 2020 at 7:49 am

    Not commenting on its skin benefits too.

    There’s SalSphere® Resveratrol - encapsulated version. disperse in cool-down phase.

  • Learntounlearn

    Member
    November 6, 2020 at 2:25 am

    Not commenting on its skin benefits because papers I saw weren’t persuasive, but I managed to dissolve 4% in plain propylene glycol. It took an hour of stirring using a magnetic stirrer. Didn’t even had to heat it.

    Can you pls share your experience wnen used in an emulsion after dissolving it in propylene glycol -Does it get oxidized or changes color of emulsion? 

  • ngarayeva001

    Member
    November 6, 2020 at 7:41 pm

    Resveratrol is an antioxidant and is prone to oxidation. It can change colour of the product when it oxidises itself. I noticed it in one of the products I made a while but I can’t tell when it happened. The moisturizer was over a year and the resveratrol powder I used in it also changed its colour. Ubiquinone is the same btw.

  • Pattsi

    Member
    November 8, 2020 at 7:36 am

    Belassi said:

    Advice? Sure. Don’t waste your time.

    Agreed.

    or if it’s intended for personal use, a suspension in hydrogel is easier to manage, shelf-life should be around 6 mo in fridge.

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