Home Cosmetic Science Talk Formulating absorption of actives

  • absorption of actives

    Posted by CansuN on September 1, 2022 at 1:41 pm

    Hi everyone,
    we are working on face serums. We use some actives. But do we have to use pentylene glycol to penetration of actives? 
    dont we use another solvent ?

    Pharma replied 2 years ago 3 Members · 2 Replies
  • 2 Replies
  • OldPerry

    Member
    September 1, 2022 at 3:50 pm

    Actives are put in skin serums as marketing story ingredients. They are not expected to have an actual effect. So, no special solvent is required.

  • Pharma

    Member
    September 1, 2022 at 7:15 pm
    Apart from what @Perry said, absorption of an ingredient and alterations thereof depend heavily on the physico-chemical properties of ingredient and those of the base they’re dissolved/dispersed in. Therefore, pentylene glycol, solvents, and any other ingredient may as well enhance, ‘disregard’ (don’t know the proper English term for it), or reduce absorption.
    Also, depending on the (alleged) pharmacological effect and many other factors, depth and speed of penetration would be key. Too fast too deep can be more detrimential than too poor too superficial ;) .
    But again, in most cases, cosmetic actives are pharmacological inactivces and solely serve the purpose of rainbow farting unicorns.

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