Home Cosmetic Science Talk Formulating Preservative lexguard HPO

  • Preservative lexguard HPO

    Posted by Nyatou on January 29, 2025 at 1:05 pm

    Hi,

    kindly asking for opinions regarding this preservative efficacy boosted with some EDTA, 2% glycols and pump containers. Composition is 45% caprylyl glycol, 30% phenoxyethanol and 10% hexylene glycol.

    It is said to be effective in water only products at 1%, an addition of 0,3% of glyceryl caprylate is highly recommended in lotions.

    Thanks in advance

    Nyatou replied 42 minutes ago 2 Members · 5 Replies
  • 5 Replies
  • PhilGeis

    Member
    January 29, 2025 at 2:10 pm

    Glycols and phenoxy are weak vs fungi.

    Highly recommended? Maybe the supplier but doubt anyone familiar with preservation would recommend glycerol caprylate

    • Nyatou

      Member
      January 29, 2025 at 4:58 pm

      I appreciate your expert input. I will add some sodium benzoate. Whenever I add some sodium benzoate I do calculations doing the Henderson–Hasselbalch equation. I have read in this group before that in order for sodium benzoate to be effective there must be 0,1% in protonated form. Is that correct? Based on my calculations 0,25% is the needed amount at pH 4.5.

      Thanks a lot!

  • PhilGeis

    Member
    January 30, 2025 at 5:17 am

    I understand and don’t find that so useful. We’re working in dynamics of formulas, microbes and consumer use. There is some degree of consistency/predictability and it more Edisonian than formulaic - derives from efficacy in formulas in use. Most folks here don’t have the luxury of on-demand validated challenge testing and post consumer use survey so they’re best advised to reapply the basic stuff within identified safe in use ranges.

    • PhilGeis

      Member
      January 30, 2025 at 8:30 am

      So you don’t think I’m just blowing you off on this, here’s an example.

      Challenge test revealed that benzoate consistently added a lot for preservation of surfactant products, esp. at pH (7.5) well above benzoic acid pKa. We’ve known this for many years before it was described and technically addressed in the literature.

      https://www.sofw.com/en/shop/articles/product/1203-enhancing-antimicrobial-efficacy-of-sodium-benzoate

      • Nyatou

        Member
        January 30, 2025 at 3:34 pm

        I am among the folks that cant afford too much testing. I try to play it safe and I can’t thank you enough for your help. My go preservatives thanks to you are Phenoxy/EHG with some sodium benzo and EDTA; euxyl k 700 ( combo of phenoxy, benzyl alcohol and potassium sorbate) and Germall plus. I have sensitive skin so a bit of different preservatives work best for me rather than throwing in the highest % of a given preservative. I do have curiosity sometimes about other preservatives but I rather be safe than sorry.

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