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What is the best actif or combination for whitening cream?
Actually i’am working for making whitening cream then i’am looking forward to hear from expert and costumers what is the best actif or combination for whitening cream:
I have very large list but I will share the available for the moment :
1)Niacinamide
2)Niacinamide with N acetyl glucosamine
3)OMEGALIGHT® (account to technical sheet it seems interesting)
4) Stabilised Vit c
5) Stabilised Vit c+ niacinamide
6)kojic Acid
7)Potassium methoxysalicylate
8)Alpha Arbutin
9)Gluconolactone (PHA)
10)Neoglow
11) other(wich one? 😊)
@Perry44 @chemicalmatt @Paprik @Abdullah @Pharma @Graillotion @Doreen @ketchito @Cafe33 @ngarayeva001 @PhilGeis @Chemist77
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This discussion was modified 2 months, 1 week ago by
Fekher.
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This discussion was modified 2 months, 1 week ago by
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33 Replies
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You do need some preservation
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Means?
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What is your policy - FA releasers? parabens? “natural”?
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Sensicare c1060
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Phenoxy with a questionable ester. Can you use EDTA? The gluconolactone (breaks down to gluconic acid) is not much.
Need something for fungi - what’s pH?
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I will not use Gluconolactone (PHA) for stability reason, ph will be in the optimal range of standard cream between 4.8 and 5.3.
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benzyl alcohol and benzoate work in formula?
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I guess but even sensicare c1060 works.
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First …Not my area. 😆
Second… surprised I did not see hexyl resorcinol on the list…. granted you listed two things by brand name….(not helpful).
When looking at a new venture…I always like to hear what George has to say on the topic….even if he is just regurgitating from dubious papers. 😉
Good luck.
Developing Skin-Lightening Products (ulprospector.com)
ulprospector.com
Developing Skin-Lightening Products
Skin lightening refers to the ability of a product to reduce hyper-pigmented areas or spots on the skin. These products, also referred to as skin-whiteners, bri
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Thanks a lot
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For your preservatives, it would be much cheaper to purchase piroctone olamine and phenoxyethanol and mix them by yourself.
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Yes, for sure however piroctone olamine is not available in my country.
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Maybe Deoxyarbutin
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Thanks but it can be irritant and also cause coloration in product as I read.
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Ad a water soluble anti oxidant
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Why adding? And why should be water soluble?
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To prevent oxidation of Deoxyarbutin in water phase
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@ngarayeva001 need your expertise 😊
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If we talk about scientifically proven skin lightening actives, it’s hydroquinone. I think kojic acid is second best in terms of quality of studies. Vitamin C derivatives have less evidence. Alpha arbutin is a derivative of hydroquinone and converts in it in skin but I don’t think anyone knows how much converts and whether it’s effective (statistically significant). I personally use 5% niacinamide, 2% NAG, 2% alpha arbutin in a o/w emulsion with 5% of ethoxydiglycol and 10% of isopropyl myristate (to enhance penetration of the actives) as a night cream and reapply sunscreen during the day in summer. My thinking process was that the all suppose to inhibit tyrasinase transfer using slightly different mechanisms and should improve efficiency of the sunscreen. I can’t tell whether it’s the sunscreen routine or combination of sunscreen and the moisturizer but I almost didn’t tan while being exposed to sun quite a lot. Keep in mind that experience of one individual is anecdotal and doesn’t replace studies.
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Thanks a lot @ngarayeva001 very interesting share and smart point of improvement the quality with solvent I have ipm other not is it important to use the other or can you input others solvents.
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I think all solvents aid with penetration of actives but some are stronger than others. Even propylene glycol will do the trick but you might want to do further research based on the type of active you will end up choosing.
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I already make a lot of researchment about vitamin c and (Mpg, glycerin) will be choice.
Now the problematic is it will be better to use maximum of solvents enhancers for a synergy or it will be better to use the best (one or two) enhancer(s) alone.
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I wonder why no one mentioned Tranexamic Acid. It was mentioned in one of the recent Beauty Brains talks from Perry and Valery
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Actually it is very expensive ingredient more then all I wrote and it it is more difficult to use in formulation then a lot of others.
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I read one paper on it (study conducted in Iran in 2014) and I didn’t think it was persuasive enough to justify the price. If you are aware of a newer studies with conclusive results please share.
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Recommended Combinations for Whitening Cream:
- Niacinamide + Alpha Arbutin + Vitamin C: This combination is highly effective in reducing dark spots and brightening the skin while improving texture and radiance.
- Kojic Acid + Glycolic Acid + Vitamin C: Excellent for targeting stubborn hyperpigmentation and improving overall skin tone and brightness.
- Licorice Extract + Tranexamic Acid + Retinol: A powerful formula for treating melasma, acne scars, and post-inflammatory hyperpigmentation.
- Azelaic Acid + Niacinamide + Alpha Arbutin: A gentle but effective combination suitable for sensitive skin, providing brightening without irritation.
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Interesting just for the first combination the form Vitamin c must have pH compatible with the compatible pH of alpha arbutin.
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Indeed, ascorbic acid requires acidic pH. But Vitamin C is a general term for many ingredients. There are ascorbic acid derivatives that are stable at neural pH
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Hi! Please, share your resourses/references for this ingredients combinations? Thank you!
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I have a hunch the comment is just ChatGPT generated
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Agree! I am a huge AI enthusiast but it is absolutely rubbish at formulating and writing anything scientifically accurate. That comment sounds like bot generated videos that flooded YouTube recently.
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Hello experts,
Can I do any mix of these combinations? or will this not be possible due to PH incompatibilities?
Appreciate any response!
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For sure you must search about pH compatibility and also ingredients compatibility then the answer almost you can’t.
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