• Formulating

  Stability of CMI MI & formalin at pH 10 for ~30 minutes

  Posted by Abdullah on June 5, 2024 at 7:21 am

  If we increase pH of a surfactant solution preserved with 0.03% CMI MI+ 0.03% formalin to pH 10-11 for ~30 minutes, then adjusted to pH 6. Will it decrease the quality and stability of CMI MI & formalin?

  If yes, then by what percentage?

  Abdullah replied 5 months, 2 weeks ago 2 Members · 4 Replies

  • CMI MI
  • formalin
• 4 Replies

• 

  PhilGeis

  Member

  June 5, 2024 at 8:05 am

  Doubt it’s stable. CMIT in any simple aqueous solution is unstable and alkaline pH is tough on it as well.

  • 

    Abdullah

    Member

    June 5, 2024 at 11:30 pm

    It is a surfactant solution.

    What about formalin at that high pH for ~30 minutes?

    • 

      PhilGeis

      Member

      June 6, 2024 at 5:56 am

      I don’t have much good information to share on that. I do understand formaldehyde is more reactive at alkaline pH. In another context I’ve used formaldehyde @pH as preservative 10 for an industrial product - uniquely effective combined with EDTA. Long term stability was not evaluated.

      • 

        Abdullah

        Member

        June 7, 2024 at 5:29 am

        Thanks

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