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Liposomal Ingredient preparation with lecithin?
Dear all,
Do you know an efficient liposomal ingredient preparation method using lecithin? Thanks
Cheers,
Joe
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5 Replies
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Hello,
This is quite a coincidence but Lucas Meyer just came to our company yesterday to demonstrate their emulsifiers and gelling agents. They also described how their material, Pro-Lipo Neo, can be used to encapsulate water soluble (up to 10%) or oil soluble (up to 0.2%) actives in liposomes for enhanced penetrations. They showed data from franz diffusion cell tests which claimed that this encapsulation increased the speed and depth of penetration while also reducing TEWL.
Of course there was a modest price tag of ~$300/kg. Not as much as some, but definitely more than others.
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Hi,
Highly appreciated for your answer. I will check them. But, isn’t it low encapsulation efficiency (up to 10%) considering other research articles? Although there are more advanced and expensive materials , even lecithin-mediated encapsulation efficiency can exceed 20%.
Best,
Joe
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I haven’t had the pleasure to look into it as deeply as you have so I don’t know very much about the “normal” amount of encapsulation. I’m just regurgitating the information that was still bouncing around my brain. If you know of other, more effective liposome creating ingredients please let me know.
One of my coworkers is trying to implement Pro-Lipo Neo into a couple existing formulations. However, due to the % of active to be encapsulated he’s looking for more effective or less costly options.
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$300 per kg!! That is scam-worthy. Lecithin graded high in phophatidylcholine runs less than $10.00 per kg. and that is the “liposomer” material of choice. Liposome formation is all in the technique, not the materials. Same holds true for niosomes, which use polyglyceryl esters in place of phospho-esters and sometimes a smidge of cholesterol. Don’t ask me why or how cholesterol fits into the picture. Beats me, but perhaps used as a processing aid.
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Yeah that price tag has been a major hindrance. I’m interested in reading up on some niosome forming materials if you know of any blends or separate materials can be used to form them. I hadn’t even heard of niosomes until your reply.
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