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D-Panthenol and Sodium Hyaluronate
Hello forum, I never found anything about adding D-Panthenol with sodium hyaluronate gel. I still don’t now if these are compatible substances or not, but whenever I prepare my sodium hyaluronate gel and then add d-panthenol the viscosity drops dramatically. What happens?
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10 Replies
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What are all the ingredients in your system?
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Acqua
Sodium hyaluronate 0.3
After 24h i add 0.5 panthenol and it gets very liquid. -
news?
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So you have only water, HA and Panthenol in your formula?
No preservative?
What is the final pH?I would suggest add panthenol into the water first and then add HA.
You can even slurry it in some humectant - propanediol works for me so the HA hydrates much faster.They should be compatible with each other.
[But we don’t know brand names, MW of HA, if panthenol is powder or liquid … ] -
I’m not really sure but my guess is that the Panthenol drops the pH and that affects the viscosity. Although, it shouldn’t affect it that much. Are you sure you are adding panthenol?
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Absolutely.
I use sodium hyaluronate (1000/1500kDa)
The system is without preservatives since i add 5% of pentylene glycol.
I’m from an Italian chemist website where we stated long time ago the incompatibility between D-Panthenol and sodium hyaluronate. The viscosity drops and it’s not because of pentylene glycol.
I’m here asking why this happens and if it affects the sodium hyaluronate properties.
Final ph is around 6.
Other ingredients that causes this, in my experience, were many forms of vitamin C. I guess due to the depolymerization of the molecule. -
If you take a look at the chemical structure of D-Panthenol you will see that it resembles a sodium hyaluronate monomer in terms of functional moities. I would presume that D-Panthenol is able to form hydrogen bonds with sodium hyaluronate and displaces the hydrogen bonds between individual hyaluronic acid chains that accounts for its viscosity.
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MarkBroussard said:…the chemical structure of D-Panthenol …resembles a sodium hyaluronate monomer in terms of functional moities. I would presume that D-Panthenol is able to form hydrogen bonds with sodium hyaluronate and displaces the hydrogen bonds between individual hyaluronic acid chains that accounts for its viscosity.@MarkBroussard Not really… True, some interactions aren’t obvious or predictable just by looking at structures. If it were the simple interaction you describe, then pentylene glycol, lactic acid and many, many more ingredients would be as likely to interfere with HA (and panthenol with all kinds of anionic polymers, respectively). Viscosity in case of hyaluronate heavily depends on the carboxylic acid moieties (or rather the sodium salt thereof). Interference would have to involve an acidic proton (not necessarily an acid = low pH but something more acidic than an alcohol) or a ‘salt overload’. Panthenol can’t do either.
I’m not aware of any incompatibility between the two and can’t see how this could happen but that doesn’t mean anything. As said, some molecules do like each other more than what meets the eye but I would assume that an interaction between two very common ingredients should be known. Maybe search on PubMed, ScienceDirect, or ResearchGate (@LeoCosm). -
MarkBroussard said:@Pharma:
Good points. @LeoCosm … have you tried adding D-Panthenol to Sodium Hylauronate solo, without the Pentylene Glycol and do you observe the same effect?
Thank you for all these informations.
Yes I tried without pentylene glycol and the result is the same.
I’m using right now this formula:
Aqua
Sodium hyaluronate 0.3
Hydrolyzed glycosaminoglycans 0.5
Niacinamide 5
Pentylene glycol 5.It is as thick as a only water and sodium hyaluronate gel.
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