• Formulating

  Switching from sodium phytate salt to phytic acid

  Posted by oneway on December 4, 2021 at 4:08 pm

  I have a gel serum that passed USP 51 with Sodium phytate as a chelator. However, the pH drifts upwards slowly over a couple of months. If I switch to Dermofeel PA-3 will I have to redo the USP 51?

  oneway replied 2 years, 11 months ago 4 Members · 4 Replies
• 4 Replies

• 

  Pharma

  Member

  December 4, 2021 at 8:15 pm

  Dermofeel PA-3 is sodium phytate in hydroalcoholic solution… what should that change?

• 

  PhilGeis

  Member

  December 5, 2021 at 12:26 am

  If ypur stbility samples (passing USP 51) were at significantly higher pH, you would repeat.

• 

  Abdullah

  Member

  December 5, 2021 at 6:53 am

  Is that pH drift because of sodium phytate? If yes then why? Because sodium phytate doesn’t do so usually. 

  Maybe adding a buffer will help.

• 

  oneway

  Member

  December 6, 2021 at 10:45 pm

  Thank you so much for your responses. I really appreciate your help and support.

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