-
Tocopherol acetate (vitamin e) emulsifier?
Hello all!
I’m trying to stabilise an aqueous vitamin E emulsion (5% in water). With classic emulsifiers (tween80, span 80 combination from 5-15%) emulsion breaks just hours after preparation in a silverson homogeniser.
I’m considering changing the emulsifier and using CREMOPHOR RH40 instead, any thoughts on it, preparation routes, etc)?Thanks in advance.
Andres -
4 Replies
-
5% Tocopheryl Acetate is going to be tough, keep in mind to solubilize you’ll need about 4x-10x the amount of emulsifier compared to oil, so you can try again but that much tween is going to feel sticky. I’d certainly prefer Cremophor, just premix with the oil before adding.
Can I ask why so much of the acetate though? It’s not the antioxidant people claim it to be and there are nicer feeling emollient options
-
I agree, that’s quite a lot.
You might actually have better luck with some of the more ‘typical’ emulsifiers/emulsifier blends - e.g. BTMS 50 or similar. Granted, you’re more likely to make a cream but you should be able to incorporate larger quantities.
Are you heating the mixture in order to form an emulsion or doing it at room temp?I’ll second EVChem’s question - why so much?
-
Ferulic acid at 0.5 to 1% or its esters are known to stabilize tocopherols. Since you are using tocopherol acetate, you may need to consider ferulic acid ethyl ester.
-
I’m using a high concentration of vitamin e because the emulsion is intended to be a nutraceutical (for poultry).
This week, I stabilised the vitamin e acetate using 15% of EUMULGIN CO 40, following EVChem’s suggestion. I’m still amazed how some emulsifiers typically used the cosmetic industry could also be used in other areas as well.
Log in to reply.