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Peptides technology
After searching the peptides technology, peptides do not work for everyone because of depending on the receptor of each nuclei cell of each person. Is this correct?
Thanks for all inputs. -
9 Replies
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Peptides, especially the small ones, usually only work in vitro. The fact that peptides are very small by nature automatically results in stronger differences regarding their binding affinity to different alleles. I don’t know if it’s really the case with cosmetic peptides and wouldn’t be astonished if it were wrong (cosmetics industries does strange and stupid things in the name of marketing) but logic dictates that cosmetic peptides should be those protein parts which bind to the active sites. Active sites rarely show point mutations due to loss of function (two exceptions are for example alcohol dehydrogenase and MDR1) and therefore shouldn’t show much differences between users.The main bias regarding ‘it works for person A but fails for person B’ is likely subjectivity and placebo effect. -
@Pharma
it works for person a but not person b.Because each person has his own cell receptors? -
I found that the extracts from herbs or botanicals work well.
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Dtdang said:…Because each person has his own cell receptors?
Not each one his own cell receptors in a strict sense. Many if not all receptors, enzymes, and other proteins have so called SNPs and other polymorphisms. If this makes a noticeable difference, we commonly refer to these often minor deviations as alleles. Some alleles make up the majority of a given protein within world population, other proteins occur in a dozen different varieties each at a substantial percentage. Many such polymorphisms are ‘silent’, they neither affect how said protein performs nor it’s binding to common xenobiotics/drugs. In case of the aforementioned alcohol dehydrogenase, most westerners have a fully functional allele (we have to spend more $$ for getting drunk) whereas an only partially functional allele is very common in the Asian population (many but by no means all Asians get drunk easier). You could compare it to hair curling or eye colour; you’re not the only one with allele X but you’re unique regarding the whole of your genome with all it’s evident and unnoticeable alleles and mutations. Apart from looking different, allele-drug interactions play only a minor role although they are more common than we want to believe. One of the most common cases are SNPs in the MDR1 which leads to certain people getting sleepy when taking antihistaminic pills whereas others can take twice as much and still won’t feel this adverse side effect. As said, we are only starting to see these differences with regard to certain pharmaceutical drugs whereas we ignore most of the minor and hence hard to determine polymorphisms. Take for example MMPs, a common target for cosmeceutical peptides: We know shit about effects of MMP polymorphisms and there’s nearly no way seeing and hence determining an effect upon dermal application of an alleged inhibitory peptide. It’s not like MDR1, a protein/gene commonly found as dysfunctional polymorphism in collies, which makes the common veterinary drug ivermectin a deadly poison for that breed.
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The problem with this discussion is that you haven’t defined what you mean by “peptides work”. Or even “botanicals and herbs work well”.
When you say they “work” what exactly are they working to do? How do you determine the difference when something works or doesn’t work?
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@Perry, work well is mean that the ingredient works as it supposes or as describe in the manufacturer’s description. For example turmeric extract for anti-aging or bear berries leaves extract for brightening
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Doesn’t work means opposite with above
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You’re getting closer. “Bear berry leaf extract brightens skin” is a specific claim that can be discussed. I don’t believe it works in a consumer noticeable way, but given controlled studies I could be convinced it does. Interestingly, this review of natural ingredients for skin lightening does not list bear berry. https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.639.5645&rep=rep1&type=pdf
As far as turmeric extract for anti-aging, that is still not a specific enough claim. What specific feature of anti-aging does turmeric “work” for? (anti-wrinkle, skin tightening, hyperpigmentation, etc.)
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It also depends on concentration, not just of the extract in the product but also of active constituents within the extract. In case of bear berries: the active brightening/whitening agent is arbutin. If you find an extract standardised for arbutin and use it at high enough levels, it’s likely to be as effective (often, plant extracts are more efficient than their single constituents) as using arbutin.Turmeric does not work. Why? I did run tests with turmeric extracts and curcumin (it’s main active constituent) and worked with a guy who tested it but also read a lot more than I did (he claimed that he literally read every halfway worthy scientific publication on curcumin/turmeric prior to 2010). Although turmeric (which, in pharmaceutical terms, stands synonymous to curcumin) is probably the one silver bullet out there, only doing what’s good and healthy for humans and nothing that harms no matter in which test you run it! Too stupid that it only does so in in vitro assays. Curcumin is so extremely lipophilic, that it does not penetrate deeper than 1 cell layer deep (maybe 2, maybe just one cell membrane depending on the way of administration). There are tricks to increase bioavailability (for example the Ayurvedic trick of combining it with pepper) by a factor of 10 but this only rises blood levels to a low two digit nanogram/ml range. Unfortunately, that’s over 1’000 times too low. Just try it out: cook some cauliflower in water wherein you add some turmeric powder. It takes about 20 minutes until it’s done and all yellow. Cut it in two and see where it’s yellow and where still white.
Japanese scientists tried to chemically modify curcumin to keep its pharmacological activities on one hand but increase water solubility and bioavailability on the other… they successfully created such molecules but alas, all showed considerable toxicity and could not be used in/on humans!Curcuminoids which don’t colour your skin bright yellow (remember, curcumin is not just THE active constituent but also the dye which turns curry yellow) make up a very small portion of turmeric extract and are acceptable antioxidants, about as good or bad as any polyphenol and hence, are about as good or bad anti-ageing compounds as the rest. But that’s all they are, average antioxidants.Other stuff in turmeric are a bit essential oil (of unpleasant smell, if you ask me) and a lot of starch and some minor stuff you find in mostly any plant.
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