-
How to formulate 60% IPA based hand sanitizer gel
I would like to know how to formulate 60% IPA hand sanitizer gel.
None of the carbomers are holding the IPA by itself. I finally got a proper gel with Rheocare C plus (carbomer) 1.7% and Polysorbate 80, but the gel in very sticky when used and leaves a thick gooey coat. -
26 Replies
-
Ultrez 20 or Ultrez 21 should do the job, simple carbomer won’t fit in here.
-
Hi Padmavathi, not exactly what you’re asking about, but you may want to check out this recent thread: https://chemistscorner.com/cosmeticsciencetalk/discussion/comment/44450#Comment_44450I’d use a much higher percentage of IPA, Ethanol would be better if possible as it shows significantly better activity against viruses. The standard for most hospitals is 85% ethanol. 80% is generally good enough, I wouldn’t go much lower.You may want to add some glycerol, a maximum of 0.725% is recommended here: https://aricjournal.biomedcentral.com/articles/10.1186/2047-2994-2-34I have no experience with Ultrez 20 or 21, but I can see that the very popular hand gel that I use has Acrylates/C 10-30 Alkyl Acrylate Crosspolymer in it, and it leaves no sticky feel at all.
-
This is very important topic , please share experience,
sticky feeling is a very common result i have the same ,-acqrylic acrylate 1.5 %
-Triethanolamin to neutralize
- ethanol 40 %
-propelen glycol 2% or more because it seems to reduce sticky feeling .
- perfume plus same amount of tween 20, 1%mixing all ingredients except a triethanolamin .
finally neutralize with triethanolaminThis is my method -
@Chemist77, i tried ultrez 10 and 20, didnt work. Will try to get ultrez 21 and try using it.
@Agate, my client wants IPA specifically as they cant get license to get ethanol. Acrylates C 10-30 alkyl acrylate crosspolymer is ultrez 20 i guess. I added propylene glycol 2%, didnt help.@bahey, i used 4% aminopropanol for neutralising, as triethanolamine or sodium hydroxide didnt work. -
a) Order of addition is pretty important
b) In case Ultrez 20 failed, then stick to good old carbomer 940 which gives the highest viscosity. Clarity might be a tad low though.c) Why the polysorbate 80?? -
@Padmavathi, fair enough, I would urge you to use at least 75% IPA, as per WHO guidelines.@bahey 40% ethanol isn’t proven to be effective against SARS-Coronaviruses (or many other viruses), it would be reckless to distribute this as a hand sanitizer. Please reformulate to contain 80% ethanol, again this is as per WHO guidelines.On a side note, Sterillium Gel also contains Cyclomethicone, which I imagine helps give it its smooth skin feel.
-
@Chemist77 i took 28% of 6% rheocare c plus solution, added 2% polysorbate 80, 3%PG. mixed it and added 60% IPA. Then neutralised with 4% aminopropanol. Gel was stable, clarity was better than that with carbopol 940. 2% or 3% rheocare c plus solution didnt give gel consistency. I used polysorbate 80 because i read in an article that it could help hold the IPA in a carbomer gel, same reason i used PG.
@Agate 60% IPA was the client requirement. I will check on the 75%.
-
Surely your client wouldn’t want to distribute a potentially ineffective product if they were aware of the issue.“Products with relatively low ethanol concentrations of up to 70 % (w/w)
usually are not sufficiently effective for hygienic hand disinfection,
when 3 ml are applied for 30 seconds. Particularly gels are considered
less effective than liquid products as they contain less ethanol. Also,
products with low ethanol contents hardly achieve virucidal activity.”75% Isopropanol blend shown to be effective against SARS-CoronavirusConclusion: “Consumers should be alerted to check the alcohol concentration in hand
sanitizers because substandard products may be marketed to the public.” -
I wonder if a Dettol gel would work well. Mind you I have no idea if carbomer can make a gel with dettol. Dilute Dettol obviously and it would be white, not clear.
-
The castor oil soap in dettol will crash the carbomer IMO.
-
Should be Ultrez 20/21 dispersed in water first. Neutralize with AMP-95, then slowly add the IPA to the gel while stirring/mixing. Also please check the neutralization ratios to get an optimum pH.
-
@Chemist77 okay will try it this way. pH was between 7 and 8.
-
When i was trying to increase ethanol concentrations it separates and form a big solid white particles,
Agate said:@Padmavathi, fair enough, I would urge you to use at least 75% IPA, as per WHO guidelines.@bahey 40% ethanol isn’t proven to be effective against SARS-Coronaviruses (or many other viruses), it would be reckless to distribute this as a hand sanitizer. Please reformulate to contain 80% ethanol, again this is as per WHO guidelines.On a side note, Sterillium Gel also contains Cyclomethicone, which I imagine helps give it its smooth skin feel.How Cyclomethicone will be dissolve in the formula ?
what about propelen glycol ?
Still don’t find anything remove stickiness of the gel ,
propelen glycol makes the gel turns to liquid ! -
Not sure if you have checked out the sample formulations from Lubrizol from UlProspector.
https://www.ulprospector.com/en/asia/PersonalCare/Suppliers/849/Lubrizol/search?k=hand+sanitizer&st=1&so=k_0&sl=88396652I’ve used IPA mixed with fragrance with Sepimax Zex or Aristoflex AVC and a humectant. I can’t use Ultrez as i don’t have the suitable neutralizer as it fails on me.
-
-
Sterillium Gel uses Tetrahydroxypropyl Ethylenediamine (Neutrol TE). I keep mentioning it because I really do like its formulation, zero stickiness.
-
Ive tried amp 95. Will try to get my hands on neutrol te and try it.
-
First the main issue is dnt use tween 80 it creates foaming soap type bubbles on hands eliminate it .
And make gel through simply by acrylate copolymer and neutralize it .then add slow IpA and mix and then add low molecular weight PEG in it totally reduce stickness problem and gives smooth velvet feel on hands .
Not PG will work in it.
We are already making in bulk quantities.
And feels so good. -
Out of general interest does anyone know what units the % Alcohol in Figure 5 from lubrizol are? weight/weight, weight/volume or volume/volume because there is a reasonable difference between the values due to the low SG of ethanol.
-
Sanitisers contain 60% V/V.
-
@bil7 thanks, will try it.
-
Padmavathi said:@Chemist77, i tried ultrez 10 and 20, didnt work. Will try to get ultrez 21 and try using it.
@Agate, my client wants IPA specifically as they cant get license to get ethanol. Acrylates C 10-30 alkyl acrylate crosspolymer is ultrez 20 i guess. I added propylene glycol 2%, didnt help.@bahey, i used 4% aminopropanol for neutralising, as triethanolamine or sodium hydroxide didnt work.Why Triethanolamin didn’t work !
-
Padmavathi said:@Chemist77, i tried ultrez 10 and 20, didnt work. Will try to get ultrez 21 and try using it.
@Agate, my client wants IPA specifically as they cant get license to get ethanol. Acrylates C 10-30 alkyl acrylate crosspolymer is ultrez 20 i guess. I added propylene glycol 2%, didnt help.@bahey, i used 4% aminopropanol for neutralising, as triethanolamine or sodium hydroxide didnt work.Hi Padmavathi,
There is no technical reason that ultrez 10 or 21 not holding IPA may be you are not using the right % of ultrez.try with higher % and also cut back to 1% pg.and neutralize with diipa. -
use AMP AS A THICKNER.
Log in to reply.