• Formulating

  What is wrong with this gel?

  Posted by Thota on March 6, 2019 at 10:50 pm

  Hi, 

  I am reacting to this formula, its giving Small red bumps on my dehydrated skin. Am I reacting to Niacinamide or Sepiplus 400 or Phenoxyethanol or is it something wrong with the formula. 

  Also wondering if niacinamide differs from supplier to supplier. 

  Water 89.5
  Sepicalm VG 2.5
  Niacimande 2
  Panthenol DL 0.5
  Allantoin 0.5

  Hyaluronic acid 0.05
  Glycerin 1.25
  Xanthan 0.1
  Sepiplus 400 1.25
  PE 9010

  Sepicalm VG is - Sodium Palmitoyl Proline, Nymphaea Alba Flower 

  Sepiplus 400 - Polyacrylate 13 (and) Polyisobutene (and) Polysorbate 20

  Pls help.

  OldPerry replied 6 years ago 5 Members · 5 Replies
• 5 Replies

• 

  belassi

  Member

  March 7, 2019 at 7:05 am

  I should think the most likely culprit is the niacinamide. Make a 2% solution of niacinamide and do a patch test for 24 hours and record the results.

• 

  pepe

  Member

  March 7, 2019 at 12:34 pm

  Phenoxyethanol in the PE9010 could be the reason. 

• 

  Thota

  Member

  March 7, 2019 at 4:17 pm

  ]pepe said:

  Phenoxyethanol in the PE9010 could be the reason. 

  Thanks, I will eliminate it and see. 

• 

  JonahRay

  Member

  March 7, 2019 at 9:51 pm

  @Thota The reaction I’ve seen from phenoxyethanol tends to be subjective irritation in the form of burning or warming (no appearance of irritation in the form of redness or scaling). I would just do a quick knock-out experiment to try to narrow it down. That’s the easiest way.

• 

  OldPerry

  Professional Chemist / Formulator

  March 7, 2019 at 11:42 pm

  Here’s a relevant paper on the subject.
  https://www.dropbox.com/s/5mknv0xql46qdns/Pehnoxyethanol-guang2016.pdf?dl=0

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