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Question about Vitamin E solubility
Hello, How much polysorbate 80 is need for dissolving 0.1% tocophryl in 100 gr water?
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11 Replies
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found it -
What was the answer?
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First add tween 80 to vit E in same amount then add to water phase
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Interesting. For fragrances you typically need a 4:1 ratio of polysorbate to fragrance. But a vitamin is clearly different.
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Two questions: 1)have you tried it yourself 2) Is the liquid transparent or cloudy? I tried to incorporate 1% of tocopheryl acetate to a serum. It took 4:1 of PEG-40 HCO (which is much better solubilizer than poly 80) to achieve clear liquid
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There is no set ratio that you can plug into a Formula and automatically get the proper solubilization. You need to determine this empirically in the Lab.
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nara said:First add tween 80 to vit E in same amount then add to water phase
I thought vitamin E was notoriously ‘difficult’ to solubilize to a clear dispersion, i.e. needs considerably more solubilizer than the same amount.
@ngarayeva001
PEG-40 HCO (which is much better solubilizer than poly 80I think it depends on what substance you’re solubilizing, whether poly 80 is better or worse than another.
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Currently water soluble form of Vitamin E available, fresh formulator have to use that one only.
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ngarayeva001 said:Two questions: 1)have you tried it yourself 2) Is the liquid transparent or cloudy? I tried to incorporate 1% of tocopheryl acetate to a serum. It took 4:1 of PEG-40 HCO (which is much better solubilizer than poly 80) to achieve clear liquidI tried to use Tween 80 to solubilise tocopherol and ended up having to use a 1:20 ratio to get a nice clear emulsion.
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What about Benzyl alcohol??
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amitvedakar said:What about Benzyl alcohol??
It should be soluble as is if you follow the percentages allowed in cosmetics (1% as per EU regulation)
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