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A product with 2% Hydroquinone keeps getting a high HQ reading using the HPLC method.
Hello, I’m new to this so please excuse me if I do something incorrectly.
Anyway, I am having a lot of difficulty with a product that is an OTC with 2% Hydroquinone in it.
Every batch is tested for HQ levels and the results consistently come back with a high recording.
Is there something that could be in the formula that is having a negative impact on the HQ?
Is there a class of chemicals that would cause an HQ level to spike?Thank you and much appreciated for ny insight you might be able to give me.
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1 Reply
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The question is is there anything in the base that is either coming through at the same time as the HQ, or something in the background that is giving a high absorbance on the UV detector.
Obvious question have you tried HPLC of base with no HQ in there to see what you get? If that’s giving a peak where you’d expect HQ to be that may be the answer, and you’ll need to revalidate the method to get around that
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