[MurtazaHakim]

Is Lonzaserve ID a better option for rinse off products ???

[MurtazaHakim]

Sodium benzoate’s activity is very low at pH above 5 and liquid hand soaps usually have pH ranging from 5.5-7.5.

[MurtazaHakim]

Why is there a need to combine CMIT with sodium benzoate and EDTA ???

Is Biocrol WS1 alone at the dosage of 0.15% w/v not sufficient to inhibit microbiological growth in rinse off products ??? 

[MurtazaHakim]

Is Biocrol WS1 from CISME Italy a good option for preservative ???

[MurtazaHakim]

What are the recommended preservatives then especially for rinse off products ???

[MurtazaHakim]

Is proxel 106 a suitable preservative to be used for hand soaps ??? 

[MurtazaHakim]

Which microbiological tests are recommended for the tap water which I am using ???

I have come across total plate count test but there may be other more reliable and accurate tests. Please provide your valuable insight on this issue. 

[MurtazaHakim]

@ozgirl the raw materials are surfactants like sodium laureth sulfate, cocamidopropyl betaine and linear alkylbenzene sulfonic acid; rheology modifiers like sodium chloride, fragrances, colorants.

@EVchem currently I am using tap water and Proxel 106 as a preservative.

Is water the primary bacterial source ???
Is a robust preservation system not sufficient to prevent microbiological growth ??? 

[MurtazaHakim]

What about the black dot on the topside for alignment??? Should it be in the middle always during the measurement of viscosity ??? 

[MurtazaHakim]

I have observed majority of products with Benzophenone-4 used for color stability. What is the recommended dosage of Benzophenone-4 for liquid hand soaps ???

[MurtazaHakim]

Can using expired fragrance in the product result in discoloration ???

[MurtazaHakim]

I tried to thicken this system in laboratory by adding pine oil to the neutralized LABSA but could not achieve the desired thickening. There are hardly any patents regarding such a product but this type of gel cleaner has a good market for sales. There were a few home care products specialist on this forum but I am unsure of their activity on this forum now. If anyone has any patent related to such a product please share.

Kind regards, 

[MurtazaHakim]

I am trying to emulate Hibicet or Savlon Hospital Concentrate. There are excipients as well but I am unsure of their composition in the final product. Isopropyl alcohol, Terpineol, Liquid deodoriser, Benzyl benzoate, d-Gluconolactone, Sodium Hydroxide and Purified water. There must be some patent disclosing something about this product.

[MurtazaHakim]

This forum is more connected to cosmetic chemists. Can you please advise of any suitable forum related to microbiology and pharmacology where my query can have reasonable response ??? 

[MurtazaHakim]

I mean is it calculated using Gas Chromatography ? Please provide trade name of C12-C14 Primary Alkyl Sulfonate. How does it differ from Linear alkylbenzene Sulphonate ?

[MurtazaHakim]

I am trying to formulate a skin cleanser with Chlorhexidine Gluconate as the active ingredient. Since CHG is cationic in nature I need surfactants which are either non-ionic, amphoteric or cationic in nature. I am aiming for stable foam coupled with antibacterial efficacy and moderate viscosity (around 1000 cps).
There is a product by Ecolab called Hydrex surgical scrub which is what I am trying to emulate.

[MurtazaHakim]

There are many products under the category of Alkyl Polyglucosides and Alkyl amine oxides. I am in search of something which is used in products like skin cleanser. I found BASF’s Plantaren series of Alkyl Polyglucosides. Furthermore are Alkylamine Oxide, Dialkyl amine Oxide and Alkyl dimethylamine Oxide all same ???

[MurtazaHakim]

ASM stands for active surfactant matter. It is very important to have correct and sufficient proportion of primary and secondary surfactants in your formulation. I once formulated a soap which resulted in sticky feeling after washing hands and the soap still remained on my palms even after rigorously rinsing hands with water. 

[MurtazaHakim]

Some colors fade under the influence of fragrance. Is there any other way to identify the effect of a particular fragrance on any formulation quickly ??? 

[MurtazaHakim]

I was informed by a fragrance manufacturer that I cannot use any fragrance for fabric softeners. Fabric softeners are cationic in nature and hence require special fragrances.

[MurtazaHakim]

Can we store Chlorhexidine Gluconate 20% solution in black IBC totes ???

[MurtazaHakim]

Can Extra Neutral Alcohol (ENA) with 96% v/v Ethanol be used for making hand Sanitizer in case of shortages in availability of Ethanol 99.9% ???

[MurtazaHakim]

If I use Chlorhexidine Gluconate 20% solution I will have to use 5 times the quantity to achieve the same active percentage. Alcohol hand rubs have around 0.5 % w/v of CHG. If I use 20% solution I will have to use it at 2.5 % w/v instead.

CHG solution on addition to Alcohol renders the solution milky and subsequent addition of water again makes the solution clear. Will the pure CHG in powdered form dissolve if I use it at 0.5% w/v in hydroalcoholic solution ???

I came across a few studies by European researchers challenging the essentiality of CHG in hand rubs. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598061/#__ffn_sectitle

Is it worth adding CHG to the product or omission of CHG does not affect the antiseptic performance ??? 

[MurtazaHakim]

Chlorhexidine Gluconate is available as a powder as well. Can we use the powder or it is advisable to use solution only ???

Secondly, is Chlorhexidine Gluconate Solution available only as 20% solution or there are other concentrations available ??? 

[MurtazaHakim]

@em88 I am looking for a viscosity of around 10,000 mm2/s