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Resveratrol solubility
I thought licorice was difficult but this is worse. Just about the only solvent I can discover is PEG-400
I’ve never heard of PEG-400, is it suitable for use in a cosmetic cream? Anyone? -
8 Replies
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PEG-400 (PEG-
is suitable in a cream or lotion. you can get it through acme hardesty or hallstar. its from sugar cane or coco fatty acids. -
By far the majority of PEG-400 is a product of the oil refinery. Be very careful how you source it if “natural” is important to you.
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Oops. Half of my reply (above) has disappeared into cyberspace.
I went on to say that I’ve never had success in making a cosmetically acceptable solution of resveratrol although I’ve not tried PEG-400.
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I’ve never had success in making a cosmetically acceptable solution of resveratrol
I was afraid of hearing something like that, and coming from a highly experienced chemist too. Yes, after reading an awful lot of literature over the past few days I have been having serious doubts. -
A material with some similar properties to resveratrol is maritime pine bark extract (Pycnogenol).
This is soluble in water and may suit your purpose.
Note that Pycnogenol is a brand name. Unbranded MPBE is a lot lower cost.
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Lemon peel bioferment looks interesting too. I just ordered some of that pine bark extract.
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Well since I have the sample I think I will try it. Solubility in alcohol is good so I’ll use 50% of (70% ethanol), and 5% propylene glycol as penetration enhancer. In airless container.
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Since I have the sample my wife has been asking me to use it. Oh well. I don’t have any PEG400 solvent so I will have to use ethanol. I discovered a BASF formula for a face cream that has 15% ethanol in it. Hopefully I can dissolve the resveratrol in the ethanol first. Unfortunately there are no prep instructions so my question to you guys is, would you add the ethanol part last?
I don’t quite have all the ingredients so any comments on my suggested substitutes are very very welcome:Test formulation for
resveratrol based on formula SC-DE-11-175-3 (COSMOS face cream, BASF)I.
Glyceryl Stearate SE 5.5%
Stearic Acid 1.5%
Cetearyl Alcohol 3%
Cegesoft® VP – try Kpangnan butter
1%Cetiol® RLF – try Schercemol 185 8%
Cegesoft® PS 6 Vegetable Oil – try
jojoba oil 6%Myritol® 312 Caprylic/Capric
Triglyceride – try Myritol 318 6%Covi-Ox® T 90 EU C Tocopherol 0.50
Argan Oil - use Mamey oil instead (relative of Argan) 1%
Xanthan Gum 0.2%
II.
Glycerin 8%
Water 42.1%
III.
Ethanol Alcohol 15%
trans-resveratrol 2%
Fragrance 0.2%
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