Home Cosmetic Science Talk Formulating Advanced Questions Butyl glycol isomers

  • Pharma

    Member
    January 9, 2020 at 8:37 pm
    These are two different chemicals, one is also known as ethylene glycol monobutyl ether (the correct chemical name would be 2-butoxyethan-1-ol but because it’s isomer 2-butoxyethan-2-ol isn’t stable, nobody uses the “-1-“) and the other ones correct name is 1,3-botanediol (it’s by definition not a glycol).
    The former is produced by treating butanol with ethylene oxide, a straight forward synthesis without isomer formation. The latter may be produced by different synthetic routes which may or may not result in by-product/isomer formation.
    BTW “pathway” is a term preferably used in biology/biosynthesis, not chemical synthesis i.e. metabolic pathways which most often don’t result in mixtures of structural isomers ;) .
  • LuisJavier

    Member
    January 9, 2020 at 9:25 pm

    Cheeky fact for me there haha. Which one is preferable for use in skincare?

  • Dr Catherine Pratt

    Member
    January 16, 2020 at 5:56 pm

    You can probably tell which one is the best by reading a suppliers list, one of those will come up all the time.

  • Pharma

    Member
    January 17, 2020 at 8:09 pm
    Uppps, I just realised that I wrote 1,3-botanediol instead of 1,3-butanediol ;( .
    I wouldn’t use either of the two.
    1,3-butanediol might work as nutrient supplement and sure, it does what similar compounds do but I’d rather go with one which also boosts preservation such as 1,2-penatanediol or similar real glycols.
    2-Butoxyethanol is not the most safe substance, has detergent properties but mostly serves as solvent or co-solvent and isn’t used for any skin care effects.
  • LuisJavier

    Member
    January 18, 2020 at 5:26 am

    Very useful clarification. I agree on use of a glycol to boost preservation. I think I will go for pentanediol or hexyl glycol.  

  • Dr Catherine Pratt

    Member
    January 18, 2020 at 1:28 pm

    Propane diol 1,3 is popular 

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