• Formulating

  What is the best technique of completely hydrating Natrosol 250 (Hydroxyethylcellulose) in Water ?

  Posted by JOJO91343 on August 7, 2022 at 11:19 pm

  Is it recommended to make a slurry with glycerin before adding it to the water phase?
  After adding it, will I start with high shear for 10 min. then, add Na OH, then mix in low shear for half an hour or more (How long will I mix in low shear)?
  What is the recommended concentration to make a clear gel? is it 0.5 to 1%?
  Your feedback is appreciated

  JOJO91343 replied 2 years, 4 months ago 4 Members · 4 Replies
• 4 Replies

• 

  ketchito

  Member

  August 8, 2022 at 11:22 am

  You can check thus doc: https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.ashland.com/file_source/Ashland/links/PHA18-101_Natrosol_250_HEC_Formulating_elegant_liquid_and_semisolid_%2520drug_products.pdf&ved=2ahUKEwitncmlkLf5AhWxBtQKHZZHBvEQFnoECAgQAQ&usg=AOvVaw3LXgR-GX_CKS6_vZBGFYQI

• 

  OldPerry

  Member

  August 8, 2022 at 12:21 pm

  Strangely, colder water works better

• 

  Abdullah

  Member

  August 8, 2022 at 3:04 pm

  Increase the pH to 10 and it will hydrate in 2 minutes. 

• 

  JOJO91343

  Member

  August 14, 2022 at 6:58 am

  Thank you all

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