Home Cosmetic Science Talk Formulating Alpha arbutin

  • Alpha arbutin

    Posted by belassi on September 6, 2018 at 7:56 pm

    I am doing some research at the moment into lightening gels and have two questions.
    1) Is niacinamide actually effective (at say, 5%)?
    2) Is it possible to prevent the oxidation of alpha-arbutin? IE, make a shelf-stable product?
    Thanks!

    ngarayeva001 replied 6 years, 2 months ago 7 Members · 33 Replies
  • 33 Replies
  • ngarayeva001

    Member
    September 6, 2018 at 8:21 pm

    @Belassi my favorite topic. 1) There are studies that show that Niacinamide is effective, especially mixed with N-Acetyl Glucosamine (4% Niacinamide and 2% of NAG). I will lookup the study tomorrow, but it was a legit one. Additionally to this, I can say that I saw a great results as a user (not very scientific I know). 2) isn’t alpha arbutin stable? I read a research that suggested it’s perfectly stable for 16 months in water solutions. Does it change color when oxidizing?

  • ngarayeva001

    Member
    September 6, 2018 at 8:56 pm

    Alpha Arbutin:
    https://onlinelibrary.wiley.com/doi/full/10.1111/ics.12275 Alpha Arbutin is stable in water solution for 16 months. Stability in a formulation depends on pH. Suppliers say that should be formulated in a range from 4 to 6.5. 
    Niacinamide:
    https://www.ncbi.nlm.nih.gov/pubmed/16029679
    Here is NAG and Niacinamide study
    https://www.jaad.org/article/S0190-9622(14)00104-2/fulltext
    It is Procter and Gamble. I will agree if you say that it might be biased.

    Cosmeceuticals for Hyperpigmentation:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663177/

  • ngarayeva001

    Member
    September 6, 2018 at 9:22 pm
  • belassi

    Member
    September 6, 2018 at 9:41 pm

    Thank you! Info very much appreciated.

  • ngarayeva001

    Member
    September 6, 2018 at 10:15 pm

    You are very welcome. I make a brightening serum with 2% Alpha Arbutine, 6% Niacinamide, 2% NAG and 2% Magnesium Ascorbyl Phosphate. It clearly works, but I don’t know what makes it work (a combination of the ingredients or just one of them). I suspect that MAP doesn’t do much at this concentration.

  • Majman

    Member
    September 7, 2018 at 5:27 pm

    @ngarayeva001 so alpha arbutin is both soluble in water and oil? Cos I intend using in a soap that has oil as part of its ingredients . Oh and for NAG, how do I get it please ,I intend formulating  a toner and serum and need the niacinamide to work effectively. 

  • ngarayeva001

    Member
    September 7, 2018 at 6:08 pm

    Are you going to add alpha arbutin to a soap?

  • Majman

    Member
    September 7, 2018 at 6:55 pm

    @ngarayeva001 to black soap formulation.. African black soap 

  • ngarayeva001

    Member
    September 7, 2018 at 9:26 pm

    You will waste a good ingredient. Soap has only  one function, to remove dirt. You will not get brightening properties of alpha arbutin by adding it to a soap. Use it in a serum instead. And make sure you adjust the pH. You can buy all ingredients discussed above in lotioncrafter.

  • Majman

    Member
    September 9, 2018 at 11:57 am

    How do I adjust ph please? Kind of a beginner 

  • Dtdang

    Member
    September 9, 2018 at 12:21 pm

    @Majman
    for adjust pH
    stirating with TEA or NaOH….
    diluting
    I like diluting

  • ngarayeva001

    Member
    September 9, 2018 at 1:00 pm

    And citric acid to reduce the pH. Solution in water.

  • Majman

    Member
    September 9, 2018 at 1:46 pm

    Thanks @ngarayeva001

  • Biochemist

    Member
    September 11, 2018 at 2:58 pm

    @Belassi @ngarayeva001 are either of you able to share the full text of the 2 Niacinamide studies @ngarayeva001 cited? ??

  • Microformulation

    Member
    September 11, 2018 at 3:16 pm

    Remember when selecting whitening actives, there is no one size fits all. You need to design each product by to the demographic and their Fitzpatrick scores.

  • ngarayeva001

    Member
    September 11, 2018 at 5:37 pm

    @Microformulation I started a thread about it, but there are no responses. I read that some ingredients that work for caucasian skin are not effective for ethnic skin and vice versa. 

  • Microformulation

    Member
    September 11, 2018 at 5:48 pm
    Real ROUGH guidance.
    Hydroquinone (avoided) and Kojic Dipalmiate (less effective) work best in Western African skin types, Irritation is an issue.
    Alpha-Arbutin works best in an Indian subcontinent and the Asian Pacific area.
    Do the botanical actives work? I am skeptical, but I include them for label copy primarily.
    Keep it simple. If you need starting formulations for either compound, there are numerous starting formulations from the distributors.
  • Majman

    Member
    September 12, 2018 at 10:30 am

    @Microformulation so kojic dip plus alpha arbutin for western African skin should be effective yeah? 

  • ngarayeva001

    Member
    September 12, 2018 at 11:42 am

    See above: “Alpha-Arbutin works best in an Indian subcontinent and the Asian Pacific area”. 

  • ngarayeva001

    Member
    September 12, 2018 at 11:45 am

    I will add from my experience that alpha arbutin works on darker shades of caucasian skin (what is called olive skin).

  • Majman

    Member
    September 12, 2018 at 12:19 pm

    @ngarayeva001 so what works for African dark tones since hydroquinone isn’t adviceable 

  • Microformulation

    Member
    September 12, 2018 at 12:26 pm
    @ngarayeva001If you look at the scale, you are referring to a III/IV.
    @Majman Kojic acid dipalmitate is the most stable.  
  • Majman

    Member
    September 12, 2018 at 12:38 pm

    @Microformulation for dark skin tones yeah?  More effective? 

  • Microformulation

    Member
    September 12, 2018 at 12:48 pm

    @Majman I wouldn’t even recommend making this product without experience. At all. The products used can be irritating. Do some Professional reading first.

  • ngarayeva001

    Member
    September 12, 2018 at 1:40 pm

    @Microformulation, what I find very confusing about Fitzpatrick scale, is to find my type in it, because on one hand I have never had a sun burn in my life (I lived in Atlanta, GA and had a lot of sun exposure) and tan easily, so my skin fits into “never burns tans easily”, on the other hand I am not that dark (not even III). And alpha-arbutin works like a charm.

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