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Hylauronic Acid freely penetrates the human skin?
Perry, in one of the modules you’ve mentioned that the Hylauronic Acid is not doing much for the skin as it is a large molecule and cannot penetrate, i have come accross this and would appreciate your opinion, please. Thank you, Irina.
“Hylauronic Acid freely penetrates the human skin in healthy volunteers
& may be used as a vehicle to carry other ingredients deep into the human
dermisb) Ageing skin loses Hylauronic acid until non is present age 60, skin
moisture level reduces with loss of elasticity causing lines and wrinkles.
Water causes a rise in extra cellular fluid giving smooth moist skin. -
7 Replies
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“b” is completely correct
but “a”, not so much. HA isn’t an acid like sulfuric or Lactic, with a fixed MW. Hyaluronic acid is actually a polymer, so…I’ve heard that lower MW versions can penetrate skin, but I don’t think I believe that. -
Bob is right. I’ve seen no evidence that Hyaluronic acid can penetrate the skin.
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@Bob and @Perry,
You mean SLMW & ULMW would not penetrate?What about studies such as these:I am interested in your opinions. -
@braveheart - I can only see the abstracts of these but the first study had the whole study. Here’s what I think.
1. The first & second studies were done on cell culture lines (as far as I can tell) The tell us nothing about whether the molecule penetrates the skin or not.2. The third study demonstrates the HA is a moisturizer. They don’t compare it to other moisturizers that are superior.3. I can’t tell from the fourth study whether HA penetrated to the dermis just (according to them) deeper into the epidermis.So, I’m still looking for data demonstrating the HA penetrates to the Dermis -
Here’s a published article relevant to this discussion:
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@MarkBroussard - thanks for the link. It appears I’m mistaken. HA does seem to penetrate the skin (at least when applied directly to the skin in a 1.3% solution).
Now, does it penetrate the skin when surrounded by emulsifiers, emollients, humectants and occlusives found in most skin lotions?And what effect does the direct application have on skin? -
@markbroussard Interesting article, thank you for sharing.
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