Dipper Rash Cream - Chemists Corner

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Dipper Rash Cream

Posted by Priya on June 2, 2014 at 8:42 am

Formulation
OIL PHASE
Arlacel 165 - 2%
Stearic Acid - 2%
Cetostearyl Alcohol - 2%
Cetyl Alcohol - 2%
Dimethecone - 1% (200/350)
Coco Butter - 0.7%
Shea Butter - 0.7%
Kokum butter - 0.7
callendula oil - 3%
olive oil - 1%
almond oil - 0.2%
NGDO ester - 2%
Vit E -0.5%
Phenoxethanol - 0.2%

Water Phase
Glycerine - 2%
Arlacell 2121- 2%
Edta - 0.1
MPS - 0.1
Aloevera EX - 1
Micronized ZnO - 1%
Boric acid - 2% (Purified AR grade)
perfume - 1%

Chemist77 replied 10 years, 6 months ago 5 Members · 9 Replies
9 Replies

Priya

Member
June 2, 2014 at 8:53 am

this is my formulation. the problem arising is about phase separation. I cant find out my reason behind phase separation. after homogenization the viscosity get dropped down & phase get separated even at pH 7.

But with ZnO- 0.5% conc. get single uniform well homogenized layer. But increase in ZnO shows drop in viscosity, separation, dull appearance.

I don know where i doing mistake.

Dear friends I need your help in this query.
Chemist77

Member
June 2, 2014 at 10:54 am

Is there phase separation or sedimentation of ZnO????? Try reading literature on ZnO stabilization.
Chemist77

Member
June 2, 2014 at 11:25 am

Priya read about diaper creams, they are generally w/o type emulsions for a longer stay on the skin and to repel the water. Your emulsifier says its a o/w one, I am not sure how this cream is going to sustain on skin when there is repetitive contact with water. Further only ZnO will not suffice, even the formula should support the function of your actives.
OldPerry

Member
June 2, 2014 at 1:04 pm

It doesn’t look like you have a polymeric stabilizer in there. That could be causing a problem. Try adding an Acryllic Polymer like Carbomer.
Chemist77

Member
June 2, 2014 at 1:16 pm

Perry IIRC we had a long discussion initiated by zink, eventually it came out that ZnO might have issues with carbomer. If you see diaper creams in general they are w/o so that main function of water repulsion in tandem with zinc oxide coating remains unaffected.
Bobzchemist

Member
June 2, 2014 at 3:55 pm

If you are going to stick with an o/w emulsion, you need the following added to your formula:

1) A suspending agent for the Zinc Oxide - I suggest Veegum Plus

2) a film former to hold the zinc oxide onto the skin - one of the Ganex’s, or something silicone based, maybe?
Priya

Member
June 4, 2014 at 4:31 am

Thanks a lot Bobz, Miliachemist & Perry.
I will try all possibilities suggested by three of you.

once again THANK YOU SO MUCH!!!!
cosmochem

Member
June 14, 2014 at 10:57 pm

Hi Priya,

I would suggest changing it to water in oil emulsion to get the full use of a Diaper Rash Cream. If in any case you have to stick with oil in water emulsion type, then it is better to use a thickener/suspending agent in aqueous phase like dehydroxanthan gum, amigel, or veegum.

It is better to avoid carbomer if you can because carbomer is incompatible with ZnO.

Hope it helps!!!!
Chemist77

Member
June 15, 2014 at 1:01 am

@cosmochem Talking of Dehydroxyxanthan Gum, can you please tell me how good it would work for a normal PAA polymer replacement in traditional hair styling gels. After you mentioned it, I tried pull up some info and honestly found quite a lot, some really dedicated and some over the top (though strictly my perception). I have worked with Xanthan but it was more of emulsion stabilization and the dispersion was never a promising gel anyway. Since I have never worked with this polymer, can you tell me if it works really well in styling gels???? The body provided by a regular carbomer is unparalleled and I was wondering if someone would share the pros and cons of this polymer before I make a sample request from suppliers. Please check the site below, it has mentioned so many benefits that the whole PAA chemistry seems useless now

http://www.thefreelibrary.com/Dehydroxanthan+gum%3A+National+Starch+researchers+provide+details+on…-a0116852519