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solubility of salicylic acid in butylene glycol
Hi to everybody,
Does anybody know the solubility of Sa in butylene glycol?
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7 Replies
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If you are using glycols, I would say 16-20* the quantity of the SA is generally a safe way to start experimenting, but it always depends on the other ingredients used in the formula, which can help SA stay in the solution , enabling you to reduce the amount of glycols.
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Thank you. I have used successfully ratio 1:15 with propanediol. I wanted it to try with butylene glycol because I seen the combo sa +butylene a lot. Does anybody know what would be the advantages of butylene glycol over propanediol?
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Any particular advice on the procedure? Sometimes I don’t know why I get crystalization. What I do is… I heat the SA with propanediol 1:15 ratio and then I mixed it with water and rest of ingredients.
Regards.
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Hi.
Increase the pH of the water phase with Sodium/Kalium Hydroxide or Sodium Citrate before adding the SA+propanediol mix. After adding the SA, the final pH should be ~3-4.
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Thank you so much!
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I heat the SA with propanediol 1:15 ratio and then I mixed it with water
Solubility of SA is affected not only by amount of solubilizer, but other additions too. When you add water you decrease the solubility. When you have pure propanediol - you have very high solubility. When you have water+propanediol mix your solubility of SA in it is different. There is a whole study on how to calculate solubility in a mix of solvents: https://pubmed.ncbi.nlm.nih.gov/16649546/
I wrote an article on reddit on how to formulate SA in DIY based on my experience, commercial products and studies. It also contains few formulas: https://www.reddit.com/r/DIYBeauty/comments/1d22zx8/formulation_guidelines_for_salicylic_acid_2_serum/
pubmed.ncbi.nlm.nih.gov
To show the applicability of a solution model, i.e. the Jouyban-Acree model, for predicting the solubility of a solute in ternary solvent systems based on model constants computed using solubility data of the solute in binary solvent systems, the solubility … Continue reading
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Your article was very helpful. Thank you so much.
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