• Formulating

  Recrystallization of azelaic acid

  Posted by Didi on July 19, 2022 at 7:42 am

  Last night I made this serum with glycolic acid, azelaic, alpha Arbutin and hyaluronic acid. Everything was smooth and fine. This morning there are crystal shards in it. I suspect it’s the azelaic acid but I’m not sure. Please help!

  Robert replied 2 years ago 3 Members · 2 Replies

  • azelaic-acid-serum-hyaluronic-acid
• 2 Replies

• 

  MarkBroussard

  Member

  July 19, 2022 at 9:22 am

  @Didi

  Azelaic Acid is only sparingly soluble, only 0.002% in water.  

• 

  Robert

  Member

  December 2, 2022 at 1:26 pm

  I have the same problem, I solubilize it at proylen glycol with heating and it turns transparent liquid and include it in cream but after cooling the day later it recrystalized again, should we just suspend the powder in creams? by this way I am not sure it will be effective on skin

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