• Science

  Ketoconazole

  Posted by Oladoo on February 11, 2020 at 7:16 am

  What are the possible solvents for ketoconazole apart from dmso?

  Oladoo replied 4 years, 2 months ago 2 Members · 4 Replies
• 4 Replies

• 

  amitvedakar

  Member

  February 12, 2020 at 5:43 am

  try in Acid

• 

  Oladoo

  Member

  February 12, 2020 at 11:46 am

  It dissolves in acid.
  However I noticed that the solution changes color almost immediately like an oxidation reaction or something. Could it be degrading? Which antioxidant can help prevent this? Finally, can this (acid) affect the concentration of ketoconazole in a formulation over time? @amitvedakar 

• 

  amitvedakar

  Member

  February 13, 2020 at 4:01 am

  after dissolving immediate dilute it & add to mix. be sure final product pH to near 6

• 

  Oladoo

  Member

  February 13, 2020 at 4:52 am

  OK. Thanks

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