How to add(dissolve) ascorbyl palmitate in oil?

Formulating

How to add(dissolve) ascorbyl palmitate in oil?

Posted by IGisele on January 23, 2015 at 1:05 am

Hi, friends. I’m a newbie here. I’m formulating a facial oil. I would like to add ascorbyl palmitate in it. It’s said that ascorbyl palmitate is oil soluble but I cannot dissolve them completely. How could I add it to the oil? Do I need any special techniques, equipment or I need to dissolve it in another solvent first? Can you give me some advice? Thank you!

Microformulation replied 7 years, 4 months ago 7 Members · 16 Replies
16 Replies

Bobzchemist

Member
January 23, 2015 at 3:41 am

What oil are you using? Sometimes it’s helpful to heat the oil and use a spatula to break up clumps as you’re heating the mixture.
IGisele

Member
January 23, 2015 at 11:19 am

Hi @Bobzchemist

I try to dissolve ascorbyl palmitate in jojoba oil. I google it and found the melting point is 116 °C. So do I need to heat to this temperature to dissolve it? Will these high temperature damage the sensitivities of both ascorbyl palmitate and jojoba oil?

I read the docs that Ascorbyl palmitate is very soluble in Ethanol and need emulsifier in oil? I have no ideas….
Bobzchemist

Member
January 23, 2015 at 2:37 pm

Jojoba oil is technically a wax, not an oil. Do you have any other oils to work with?
belassi

Member
January 23, 2015 at 7:05 pm

Just a suggestion: you could try dissolving it in an alternative nonpolar, such as an ester, eg Myritol 318.
Bill_Toge

Member
January 23, 2015 at 9:07 pm

the melting point is for the pure substance, not a solution

if it’s reasonably soluble in the oil you want to dissolve it in, it’ll dissolve at a much lower temperature than the melting point

I agree with @Belassi; since it’s an ester, try dissolving it in another ester
IGisele

Member
January 24, 2015 at 12:06 am

Thanks @Belassi @Bill_Toge , I will try Myritol 318 and heat it

Hope it works!
belassi

Member
January 24, 2015 at 1:59 am

Don’t get it too hot, capric/caprylic triglycerides is water thin to start with and will break down if you get it too hot.
IGisele

Member
January 26, 2015 at 1:28 am

@Belassi, finally I dissolved the ascorbyl palmitate in capric/caprylic triglycerides with heating, thanks. But due to my knowledge, vitamin c is very temperature sensitive. Is it OK to heat it? I think I heat to appx 70C to dissolve it.
belassi

Member
January 26, 2015 at 2:51 am

I honestly don’t know, perhaps someone else can help.
IGisele

Member
January 26, 2015 at 3:21 pm

@Belassi, will the capric/caprylic triglycerides become solid after heating? the fractionated coconut oil become solid with ascorbyl palmitate after one day….
Bobzchemist

Member
January 26, 2015 at 4:26 pm

CCT is a liquid at almost all temperatures. Look up solidification/melting points to find this information easily for almost any material.
cossci21

Member
February 4, 2015 at 3:58 am

how much ascorbyl palmitate are you adding?
maybe you are adding too much? I have used it in oils eg sunflower no problem without heating to 70°C
jeremien

Member
July 13, 2017 at 2:40 pm

@cossci21, at which concentration is ascorbyl palmitate soluble in sunflower oil?
Microformulation

Member
July 13, 2017 at 2:53 pm

This is an old post. almost 2 1/2 years old. It is unlikely you will get an answer. However, those questions can be easily found in the technical documents.
jeremien

Member
July 13, 2017 at 3:33 pm

I was just looking to the technical documents, and only very general considerations on the solubility of ascorbyl palmitate in oil
Microformulation

Member
July 13, 2017 at 3:45 pm

I have never had an issue getting this information, but in the end it will take some experimentation.