• Eucasol

    Posted by belassi on December 26, 2017 at 4:12 pm

    I’ve been asked if I can do a knock-off of this. However some of the ingredients are unfamiliar so I will be grateful if you guys can answer some questions:
    1. Triethylene glycol - what’s this, and it’s purpose?
    2. 
    Isobornyl acetate - same questions.
    3. 
    Chlorhexidine digluconate - is this a preservative?
    Thank you!

    belassi replied 6 years, 4 months ago 6 Members · 13 Replies
  • 13 Replies
  • belassi

    Member
    December 26, 2017 at 7:59 pm

    3. I looked this up and apparently it is the stuff used in dental mouthwash. Seems like a strange choice in a topical spray.

  • gld010

    Member
    December 26, 2017 at 8:22 pm

    Triethylene Glycol is used as a disinfectant when aerosolized and Isobornyl Acetate is an earthy, pine-y scent. Sounds like whatever you’re making is like Pine-Sol for your mouth. :)

  • belassi

    Member
    December 26, 2017 at 8:46 pm

    Alcohol, Propylene glycol, Water (Aqua), Eucalyptus globulus leaf Oil, Rosmarinus officinalis (Rosemary) leaf Oil, Triethylene glycol, Mentha arvensis leaf Oil, Fragrance (Parfum), Isopropyl myristate, Isobornyl acetate, Juniperus communis fruit Oil (Juniper), Camphor, Picea excelsa leaf Oil, Pinus pumilio branch/leaf Oil, Pinus sylvestris leaf Oil, Menthol, Linoleic acid, Eugenia caryophyllus (Clove) flower Oil, Chlorhexidine digluconate, Linolenic acid, Limonene, Benzyl alcohol, Eugenol, Geraniol, Citronellol, Coumarin, Linalool, Benzyl benzoate
    - apparently it is not a mouth spray but a spray used topically eg at night to ease breathing. (Vick Vaporub style)
    It doesn’t look as if the ingredients are listed in correct order, to me. I don’t think i can get triethylene glycol, can anyone suggest a replacement?
    And I don’t have any isopropyl myristate, but from the description, it looks like I might replace it with another ester, say Schercemol 185: (from ULP) 
    Schercemol™ 185 Ester is a very mild emollient with a low level of skin and eye irritation as compared to other emollients such as isopropyl myristate.

  • belassi

    Member
    December 26, 2017 at 9:22 pm

    Possible starting point (comments invited!)

    Alcohol,                30%

    Water (Aqua),   q/s (54%)

    Propylene glycol,    5%

    Eucalyptus globulus leaf Oil,  2%

    Rosmarinus officinalis (Rosemary) leaf Oil, 1%

    Mentha arvensis leaf Oil, 1%

    SHS Ester 185, 2%

    Fragrance (Parfum), Isobornyl acetate, -> herbal fragrance 0.5%

    Juniperus communis fruit Oil (Juniper), 1%

    Camphor,  0.2%

    Picea excelsa leaf Oil, (spruce) 1%

    Pinus pumilio branch/leaf Oil, (pine) 1%

    Menthol,  ?

    Eugenia caryophyllus (Clove) flower Oil,  0.2%

  • DAS

    Member
    December 26, 2017 at 9:50 pm

    The clorhexidine is used as a preservative, but I wouldn’t use in that formula. In general is used in hand soap in medicine at 4%, the big advantage is that you can use it over damaged skin too, so it has replaced at some point the classic iodine. Its also widely used in odontology at lower percentages.

    The disadvantage is that doesn’t cover a wide range, like fungi and gram- unless you use it at high percentage. That’s why is generally used in combination. 

    I recommend it, but for products that will be in contact with the skin. A cream with 0.5% is ideal and can even be used as disinfectant of wounds. 

  • Microformulation

    Member
    December 26, 2017 at 10:12 pm

    Chlorhexidine is also used dental products and prescription mouthwashes like Peridex to treat gingivitis. https://www.drugs.com/mtm/peridex-oral-rinse.html

  • Chemist77

    Member
    December 27, 2017 at 5:44 am

    I use digluconate salt as anti bacterial agent, never as a preservative though. Can it be used as a preservative @DAS since I still use a preservative in presence of Digluconate.

  • belassi

    Member
    December 27, 2017 at 5:59 am

    With 30% alcohol and 7% essential oils, would a preservative be necessary?

  • Chemist77

    Member
    December 27, 2017 at 6:32 am

    No in that case no @Belassi, I mentioned that for my other surfactant based preparations. 

  • OldPerry

    Member
    December 27, 2017 at 6:15 pm

    Your formula looks reasonable. You probably don’t need 2% SHS ester though. I’d start with 1%

  • belassi

    Member
    December 27, 2017 at 6:51 pm

    Good, thanks. How much menthol would be reasonable, do you think?

  • OldPerry

    Member
    December 27, 2017 at 10:41 pm

    I guess it depends on what the Menthol is doing in the formula. If it’s flavoring 1% would be a good place to start.

  • belassi

    Member
    December 27, 2017 at 11:09 pm

    No, it’s for topical use. Like VapoRub. For inhalation, to ease blocked nose.

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