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  • Equipment validation and NPD

    Posted by Herbnerd on March 16, 2020 at 12:39 am

    Do any of you also conduct equipment validation when assessing your lab equipment? 

    My vacuum mixer seems not to be drawing a decent vacuum (enough to de-aerate a tooth gel) and just wondering if/how I can validate whether or not I am getting enough vacuum across the mixer. 

    To roughly test the vacuum I made a solution of Sorbitol 70% with Silicon Dioxide (Zeodent 117/168) which is a watery gel - and after 60 mins with -200 mmHg it still contains lots of bubbles, after a further 60 mins at -600 mmHg there is no improvement.

    Vacuum clearly not working well - but how to validate this?

    Herbnerd replied 4 years ago 2 Members · 2 Replies
  • 2 Replies
  • bill_toge

    Member
    March 16, 2020 at 12:57 am

    a vacuum pump can only do so much; the best way to avoid bubbles is to avoid introducing air into the product in the first place (prevention being better than cure)

  • Herbnerd

    Member
    March 16, 2020 at 7:11 pm

    Bill_Toge said:

    a vacuum pump can only do so much; the best way to avoid bubbles is to avoid introducing air into the product in the first place (prevention being better than cure)

    So true - but it seems my vacuum mixer is whipping more air into the product than I started with. 

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