Most effective anti itch ingredients? OTC/Non OTC

Thinking particularly for atopic dermatitis, the FDA has approved some OTC drug ingredients for this use and there are also non approved topicals available that could help, but I'm have little experience with this so and suggestions would be appreciated. Fine with either making an OTC drug or non-drug formula.

FDA Approved and regulated topicals
  1. Menthol (Counterirritant) <= 1%
  2. Camphor (Counterirritant) <= 11%
  3. Hydrocortisone (Corticosteroids) 0.5 - 1%
  4. Lidocaine (Local Anesthetic) <= 5%

Non approved topicals
  1. Burow's solution, an astringent aqueous solution of aluminium acetate, is shown to soothe and to relieve itching.
  2. Olive oil
  3. Calamine lotion, containing zinc oxide and iron(III) oxide, is a traditional remedy for mild itching, such as that typically associated with chicken pox – although the U.S. Food and Drug Administration has asserted that it has little if any effect.
  4. Paste of sodium bicarbonate (baking soda) and water, applied topically.
  5. Ammonium hydroxide (household ammonia), applied topically can relieve some kinds of insect stings which itch, such as mosquito bites, by neutralizing an acid component of the sting.
  6. Papain-based topical creams.
  7. Coal Tar.
  8. Vitamin B12.


  • BelassiBelassi Member
    I am very surprised you didn't mention urea.
    Cosmetic Brand Creation. Concept to name to IMPI search to logo and brand registration. In-house graphic design inc. Pantone specs. Cosmetic label and box design & graphics.
  • ZinkZink Member
    It's not an exhaustive list :)
  • Not sure if this will help you, but it could be worth a look...

  • ZinkZink Member
    Don't think that helps much, still looking for advice, I guess it's time to ask eczema prosumers?
  • Take a look at pramoxine hydrochloride. It's a very good topical analgesic. Combine that with camphor and conventional moisturizers and you are on your way to a soothing preparation.
  • MarkBroussardMarkBroussard Member, Professional Chemist
    There's also Anti Monkey Butt Powder with Calomine
    Chemist/Microbiologist formulating in the Organic & Naturals arena under ECOCert/Natural Products Assn/Whole Foods/National Organic Program guidelines focused skincare & haircare products. 

    See website for details
  • ZinkZink Member
    So using pramoxine hydrochloride I'd have to get a contract manufacturer to make it and do a FDA new drug registration I believe, but where do people source this? China?

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