How do they support this claim and what ingredient does it? (Up to 95% less hairfall)

This shampoo from Clair claims Up to 95% less hairfall. How do they support claims like this and what ingredient work for this.

Water, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Dimethiconol and TEA-Dodecylbenzenesulfonate, Zinc Pyrithione, Propylene Glycol, Dimethicone and Laureth-4 and Laureth-23 and poloxamer 407, Perfume, Carbomer, Climbazole, Sodium Chloride, Phenoxyethanol, Sodium Hydroxide, Sodium Salicylate, Guar Hydroxypropyltrimonium Chloride, Zinc Sulfate, Citric Acid, Glycerin, PEG-45M, PPG-9, Helianthus Annuus (Sunflower) Seed Oil, Lysine MonoHydrochloride, Panthenol, Tocopheryl Acetate, Pyridoxine Hydrochloride, Sodium Ascorbyl Phosphate, Panax Ginseng Root Extract, Zinc Gluconate, CI 15985


  • PerryPerry Administrator, Professional Chemist
    There are two things.  

    1. First they say "up to 95%" so that could mean 0 to 95%.  It's a pretty broad claim

    2. It also depends on what they define as hairfall. They probably will say hair fall is hair breakage. Then they have a little asterisk where they likely say when used in combination with a conditioner.  Then they do a robotic combing study. They count how many hairs break off with and without treatment and that works out to be up to 95% less breaking.

    That's how I would do it anyway.
  • SylSyl Member
    This is sneaky! Not ok in my book.
  • PerryPerry Administrator, Professional Chemist
    @Syl - Welcome to the wonderful world of cosmetic claims substantiation!
  • @Perry thanks. 
    I will do such claim too hahahah. 
  • SylSyl Member
    How many times will a reasonable person buy this shampoo if they keep losing their hair? :-)
  • @Syl maybe for a few months
  • PhilGeisPhilGeis Member, Professional formulator
    Consider testing your product to any claim - rather than looking for support.
  • @PhilGeis good point but how you claim and support it is very important especially in a product that doesn't do what people think it does for example reducing hair fall by shampooing it. 

  • SylSyl Member
    @ Abdullah, a new twist on this theme It appears that if you reduce oxidative stress you will lose less hair. We need to add anti-oxidants to our formulas...:-)

    Below is an article from Happi now Magazine.
    Over two-thirds of adults in the US are concerned with hair loss, yet the majority leave it untreated, believing hair loss is caused by uncontrollable factors like age or genetics. Scientists and dermatologists have suspected oxidative stress at the scalp surface may also be a hair loss culprit. 
    Oxidative stress comes from damaging free radicals, which we regularly encounter from environmental sources like UV and pollution. Free radicals are known to accelerate skin aging and to disturb the scalp skin barrier. 
    Research publishedin the International Journal of Cosmetic Science confirms a specific antioxidant approach works to reduce excessive hair loss by reducing scalp oxidative stress. The tested technology has become the clinically-proven Hair Anchor Blend in KeepItAnchored’s hair care systems. 
    “This research, over a decade in the making, sheds light on an issue faced by the majority of the population. The findings enable us to offer a first-of-its-kind preventative solution with KeepItAnchored’s systems, strengthening hair at the root to keep more of the hair you have, and less in the drain or brush,” said Alex Keith, CEO of Procter & Gamble’s Beauty Division. 
    Designed with dermatologists from Cleveland Clinic as well as hair, scalp, and clinical scientists, the study enlisted 300 men and women between the ages of 18-65 and used 10 methods to create a detailed scalp-to-hair root model. 
    Findings from the six-month, randomized, double-blinded, placebo-controlled clinical study include the following:
    • Those using the antioxidant formulas had 2,400 more hair fibers than those using the placebo;
    • Scalp oxidative stress affects everyone with hair – even those without scalp issues;
    • Unlike your DNA or age, oxidative stress is a cause of hair loss that can be controlled with simple changes to normal hair care routines;
    • Reducing scalp oxidative stress leads to improved scalp condition, less hair loss and more hair remaining on the head. Results were measurable and noticeable; and
    • The antioxidant approach was most effective on those who had more hair at the start.
    The full body of research, entitled “Reducing hair loss by reducing scalp oxidative stress,” publishes online on October 12, and will appear in the November 2021 print issue from the International Journal of Cosmetic Science. 

  • @Syl good information
    Appreciate it
  • PhilGeisPhilGeis Member, Professional formulator
    Abdullah said:
    @PhilGeis good point but how you claim and support it is very important especially in a product that doesn't do what people think it does for example reducing hair fall by shampooing it. 
    Not sure I understand - if you haven't support, haven't applied some metric in development that demonstrates, the claim is fantasy - pretty common in cosmetic biz.
    If you're asking how to communicate a product benefit valid or fantasy - that's  marketing/advertising. 
  • @PhilGeis i was asking how to communicate a product benefit. 
  • PhilGeisPhilGeis Member, Professional formulator
    to consumers? that's marketing and advertising and only indirectly technical

    be aware
  • @PhilGeis this study is interesting.

    What are the best ingredients or antioxicants for Oxidative stress to apply from a leave on product for scalp?

  • SylSyl Member
    @Abdullah: It appears that P&G is using caffeine which has been marketed for hair loss for a while.
    Ankored Shampoo and Essence.




  • SylSyl Member
    @PhilGeis is correct, it is marketing and indirectly technical.
  • Interestiny It also has Piroctone Olamine in all the products. 

    Is it as preservative or dandruff or it has any effect for Oxidative stress? 
  • SylSyl Member
    It is used for dandruff and associated hair thinning.

    Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each one of the three shampoos in the market containing either 1% ketoconazole (KTZ), 1% piroctone olamine (PTO) or 1% zinc pyrithione (ZPT). Shampoos had to be used 2-3 times a week for 6 months. Hair shedding during shampoo was evaluated semiquantitatively. Hair density on the vertex was evaluated on photographs using a Dermaphot. Trichograms were used for determining the anagen hair percentage and the mean proximal hair shaft diameter using computerized image analysis. The sebum excretion rate (SER, mug cm(-2) h(-1)) was also measured using a Sebumeter. The three treatments cleared pruritus and dandruff rapidly. At end point, hair density was unchanged, although hair shedding was decreased (KTZ: -17.3%, PTO: -16.5%, ZPT: -10.1%) and the anagen hair percentage was increased (KTZ: 4.9%, PTO: 7.9%, ZPT: 6.8%). The effect on the mean hair shaft diameter was contrasted between the three groups of volunteers (KTZ: 5.4%, PTO: 7.7%, ZPT: -2.2%). In conclusion, telogen effluvium was controlled by KTZ, PTO and ZPT shampoos at 1% concentration. In addition, KTZ and PTO increased the mean hair shaft thickness while discretely decreasing the sebum output at the skin surface.
  • AbdullahAbdullah Member
    edited October 2021
    @Syl thanks a lot
  • SylSyl Member
    Piroctone Olamine is also an antifungal, in the US dandruff shampoos are considered drugs.
  • DaveStoneDaveStone Member
    edited October 2021
    "The novel topical technology evaluated was complex, requiring the development of a new formulation. Each functional material was selected for its known effects on skin and scalp. With the principle components of zinc pyrithione, piroctone olamine and zinc carbonate, the aim was to improve the skin barrier function and mitigate oxidative stress. Since oxidative stress can originate from multiple sources, we sought anti-oxidant materials that could function by multiple mechanisms. Specifically, zinc has antioxidant properties [31]. Piroctone olamine is an iron chelator [32], and iron chelation has been shown to reduce oxidative stress in skin by preventing formation of iron-catalysed oxygen radicals [33, 34]. Piroctone olamine and zinc pyrithione are known anti-Malassezia agents [35]. Zinc carbonate potentiates the effects of zinc pyrithione [36]. In addition to these primary materials, secondary anti-oxidants and barrier improvement materials were also included. Niacinamide [37] and caffeine [38] both have antioxidant properties. Both niacinamide [37] and panthenol [39] improve skin hydration and skin barrier, thus reducing the tissue stress associated with poor barrier. As effective as these materials are intrinsically, effective scalp delivery vehicles were developed to enable the realization of these activities."
    There's also a chart showing how much of each is ingredient is added. Leave-on products had more niacinimide than anything, followed by caffeine. The shampoo had more of the zinc compounds than anything.
  • PhilGeisPhilGeis Member, Professional formulator
    Piroctone olamine was used for dandruff.  Hair thinning was not its intent - this is tangentdial - a potential, limited benefit.  P&G never made the relevant claim.
  • Does antioxidants reduce oxidative stress?

    If yes then which one is stronger antioxidants?

    1. Ingredients like Piroctone Olamine ,niacinamide or Panthenol as here.

    2. Ingredients like tocopherol, BHT or ascorbic acid. 

    Also for chelating iron, does chelating iron with EDTA or phytic acid have the same effect as Piroctone Olamine of this same purpose? 
  • Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study
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