Do you think it makes a difference if the acid is L or D. Like L Mandelic acid vs D Mandelic and how it would work? I believe the marketing term is chirally correct.
As @Perry said, chirality is important for biological systems and hence pharmaceuticals, but sometimes, just sometimes, chirality has also an effect on physics. Something deep in my brain tells me that there are a few cosmetics ingredients with a mild difference between stereoisomers... it wasn't simple acids.
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As far as I know only panthenol (topical), dextro vs levo.