Buffering Question

DavidWDavidW Member, PCF student
I am working on samples for a client of various skin peels using different acids.  Some are glycolic, salicylic, lactic, mandelic.  Not all in the same product but some have more than one acid.  Over time the pH of some of the products are drifting downward.  Does anyone have experience with buffering these types of products?  Thanks.

Comments

  • might try a combo of Citric acid and NaOH 50% soln. raise it up then get it into the 6.5pH range
  • DavidWDavidW Member, PCF student
    But it's a peel.  The final pH is around 2.7 to 3.2
  • @DavidW oh gotcha well just lower it with citric then raise it to 3.0 with NaOH
  • That might work but you're better off using an actual buffer system (acid + conjugate base). Use a buffer table (citric acid + sodium citrate). Otherwise a phosphate-citrate buffer should work in that range.
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