Benzethonium Chloride (BZT)

Does anyone work with this on a regular basis?  I am having difficulty getting any of my formulas to work with our hplc methods.  Does BZT interact in any specific way to anionic/cationic surfactants that I should be wary of?  Right now I am focusing on getting my hand soap to register BZT correctly on HPLC.  All I have in my formula is Water, SLES,SLS, Coco Betaine, and (NaCl) Salt.  Without divulging too much info I'm at ~30% Surfactants ~70% Water.  If you need more specifics to give advice let me know and I'll respond as quick as I can.  Thanks (first post btw!)


  • johnbjohnb Member, Professional Chemist
    Benzethonium chloride (HYAMINE 1622) is a cationic surfactant usually employed as an antimicrobial.
    BTZ will react with the anionic surfactants (SLES, SLS) in your formula to form an inert waxy product.
  • chickenskinchickenskin Member
    edited September 2016
    It actually came out clear in my solution, but you are right its incompatible due to it failing hplc haha.  Yeah i don't know what I was thinking, i think i just got caught up in trying to make something quick without researching
  • Hi chemists, the compound Benzalconium cloride is the same as Benzethonium cloride?, and if not the same, its chemical behavior is similar?
  • @Dilfre no these chemicals are different in structure and in behaviour 
  • thanks for your fast repply chickenskin, I appreciate that.
  • johnbjohnb Member, Professional Chemist
    Benzethonium chloride and benzalknium chloride are both cationic surfactants and show similar incompatibility with anionic materials.
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