Home Cosmetic Science Talk Formulating Best thickening agents for (Benzoyl) Peroxide containing OIW formulas? List of options

  • Best thickening agents for (Benzoyl) Peroxide containing OIW formulas? List of options

    Posted by zink on May 29, 2019 at 4:02 pm
    Thickening BP or any peroxide containing formulas can be tricky, because peroxides can in some cases attack the thickeners, thinning the formula and usually decreasing shelf-life. You ideally want less than 10% degradation over 1 year.

    Vantage recommends

    carbomer (not the most stable option, release of benzoic acid results in depolymerization, Bollinger, Journal of Pharmaceutical Science, 1977, vol 5)
    magnesium aluminum silicate (mixed with HEC work better than carbomer, but still thinning and degradation is significant)
    bentonite
    PEG-14M
    PEG/PPG-4/12 dimethicone
    methyl methacrylate/glycol dimethacrylate crosspolymer
    lauryl methacrylate/glycol dimethacrylate crosspolymer
    hydroxypropyl methylcellulose
    acrylates C10-30 alkyl acrylate crosspolymer
    cetyl alcohol
    cetearyl alcohol
    xanthan gum (works, but at high use rates is a bit sticky and drying)
    kaolin

    Other recommended thickeners
    Simulgel 600, Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer & Isohexadecane & Polysorbate 80
    Sepigel 305, Polyacrylamide & C13-14 Isoparaffin & Laureth-7 (can be a bit oily feeling)
    Scleroitum Gum (works about as well as xanthan gum, bit less drying skin feel).

    Any other good options here? Should handle 10% alcohol and 10% lipids.

    zink replied 4 years, 10 months ago 1 Member · 0 Replies
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