I completely agree with Tobias that Urea is insoluble in any oil/lipid media. @Nouranm However, you may make a mixture/paste, which is known in many pharmacopeias and among dermatologists. It includes micronized Urea and fatty base. Another approach can be efficient - the Glycerin/Oil (waterless emulsion) or water/oil HIPE emulsion. It will look as a nice occlusive ointment. You may also find useful including Lactic acid along with some antimicrobial ingredients in this formulation since the chronic cracks are result of untreated infectious inflammation. o/w emulsions with the same actives would be less effective.
Hello guys, Does anyone has an idea how can I dissolve 10% urea in an ointment for heels with SA and white petroleum, but without water as I want it too heavy for cracks
@em88 I don't see any incompatibilities with Urea and SA. Formulating emulsions with them could become a pain but nice pleasant emulsions are possible to create, especially with low Urea concentrations ( up to 10-15%).
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