heel ointment

NouranmNouranm Member
Hello guys, Does anyone has an idea how can I dissolve 10% urea in an ointment for heels with SA and white petroleum, but without water as I want it too heavy for cracks

Comments

  • GordofGordof Member
    due to the fact that it is rather insoluble in oil, I don't think you can manage it without adding alcohol or water to the formulation.

    you can do it with Glycerol the solubility is very equal to water 500g /L but it would mean that you add like 20 % Glycerin to your formulation with all the problems that brings. and I am not very sure that it will stay solubilized in that kind of Formulation. 

    Does someone have another idea? 

    Tobias 
  • I completely agree with Tobias that Urea is insoluble in any oil/lipid media. 
    @Nouranm However, you may make a mixture/paste, which is known in many pharmacopeias and among dermatologists. It includes micronized Urea and fatty base. 
    Another approach can be efficient - the Glycerin/Oil (waterless emulsion) or water/oil HIPE  emulsion. It will look as a nice occlusive ointment. You may also find useful including Lactic acid along with some antimicrobial ingredients in this formulation since the chronic cracks are result of untreated infectious inflammation. 
    o/w emulsions with the same actives would be less effective. 
  • @vitalys can you give me a source to learn about that paste and emulsions you talked about?
  • @Gordof what do you think about w/o emulsion?
  • amitvedakaramitvedakar Member
    edited September 3
    equal PG.also add HP wax.
  • em88em88 Member
    vitalys said:
    I completely agree with Tobias that Urea is insoluble in any oil/lipid media. 
    @Nouranm However, you may make a mixture/paste, which is known in many pharmacopeias and among dermatologists. It includes micronized Urea and fatty base. 
    Another approach can be efficient - the Glycerin/Oil (waterless emulsion) or water/oil HIPE  emulsion. It will look as a nice occlusive ointment. You may also find useful including Lactic acid along with some antimicrobial ingredients in this formulation since the chronic cracks are result of untreated infectious inflammation. 
    o/w emulsions with the same actives would be less effective. 
    I am working on this. The cream is unstable, the same as urea. SA (2%) and urea seem to not be very compatible in creams.
  • em88em88 Member
    Nouranm said:
    Hello guys, Does anyone has an idea how can I dissolve 10% urea in an ointment for heels with SA and white petroleum, but without water as I want it too heavy for cracks
    The approach can be with white petroleum, PEGs, and glycerin. But the ointment will not be very pleasant during applications.
  • well, i would say a W/O emulsion is a good possibility to get the occlusive of oil and although get the urea in the WAter Phase solubilized. 

    it will not be the Easiest of Formulations to stabilize but it is possible i would say


  • @em88 I don't see any incompatibilities with Urea and SA. Formulating emulsions with them could become a pain but nice pleasant emulsions are possible to create, especially with low Urea concentrations ( up to 10-15%).  

  • vitalys said:
    @em88 I don't see any incompatibilities with Urea and SA. Formulating emulsions with them could become a pain but nice pleasant emulsions are possible to create, especially with low Urea concentrations ( up to 10-15%).  

    pH is the issue. Salicylic acid has keratolytic properties when used as acid. Urea, on the other hand, is not stable at acidic pH.
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